Careers

Septic shock is a common and highly lethal ICU condition; Indian ICU data report mortality of up to 50–55%. A key driver of refractory vasodilation is excessive nitric oxide production through the NO–cGMP pathway. Methylene blue, an inhibitor of this pathway, is inexpensive and widely available, but high-quality evidence on its early use in septic shock — particularly from Indian ICUs — is lacking.

BLUE-SHOCK is a single-centre, prospective, randomized, open-label, blinded outcome assessment (PROBE), parallel-group controlled trial. One hundred adults meeting Sepsis-3 criteria for septic shock will be randomized 1:1, within 24 hours of vasopressor initiation, to receive either adjunctive intravenous methylene blue along with standard guideline-based care, or standard care alone.

The primary outcome is time to shock reversal (cessation of vasopressors for ≥ 6 consecutive hours). Secondary outcomes include cumulative norepinephrine-equivalent dose, mean arterial pressure, cardiac output and systemic vascular resistance over the first 48 hours, lactate clearance, duration of mechanical ventilation, ICU length of stay, 28-day mortality, adverse events, and ICU treatment cost. The study will also explore biomarker-based (IL-6, procalcitonin) and hemodynamic phenotypes associated with treatment response.

Salary : Rs.36,400/- p.m

No of Vacancy : One

Bedside and technical support for trial conduct across the Medical and Surgical ICUs, including:

• Daily screening of ICU admissions for septic shock and assistance in identifying eligible patients within the 24-hour enrolment window.
• Assisting the investigators in the informed consent process and in maintaining consent documentation.
• Prospective bedside collection of clinical, hemodynamic and laboratory data at the predefined time points — vasopressor doses, MAP, cardiac output and SVR, lactate, ABG and organ-support parameters.
• Operating and assisting with cardiac output monitoring devices as per standardized protocols; escalating technical faults promptly.
• Collection, labelling, processing, aliquoting, storage and transport of blood samples for biomarker (IL-6, procalcitonin) and routine laboratory analysis, and liaison with the central laboratory.
• Accurate and timely completion of case record forms and data entry into the study database; correction of queries raised during data validation.
• Follow-up of enrolled participants for outcome data up to day 28, including record retrieval and telephonic follow-up where required.
• Maintaining study logs, drug accountability records, sample inventories and consumable stock.
• Reporting any suspected adverse event immediately to the Project Research Scientist–I and the Principal Investigator.
• Assisting in study documentation, filing and audit preparation, and any other technical task assigned by the Principal Investigator in connection with the project.

Preferred Qualifications: 

Essential:

• Graduate degree in Science / Life Sciences / Nursing (B.Sc. Nursing) / Medical Laboratory Technology / Allied Health Sciences from a recognized university with 3 years of relevant experience; OR
• Post-graduate degree in a relevant subject (Life Sciences, Microbiology, Biochemistry, Biotechnology, Clinical Research, Allied Health Sciences) from a recognized university.

Desirable:

• Training or certification in Good Clinical Practice.
• Experience with phlebotomy and sample processing, and familiarity with ICU monitoring equipment.
• Proficiency in computer applications, data entry and electronic data capture systems (MS Excel, REDCap or equivalent).

Age Limit: 35 Years

Preferred Language: English

Tentative Date of Joining : 15th  October 2026

To Apply: E-mail cover letter and curriculum vitae with 3 references (names and email addresses / phone numbers) by on or before 9th October 2026 to mathangi.krishnakumar@stjohns.in & cc to hr@sjri.res.in