Publications

Purpose: The purpose of the present study was to find the correlation between gingival crevicular fluid (GCF)/peri-implant crevicular fluid (PICF) alkaline phosphatase (ALP) levels and implant stability in controlled diabetic patients. Materials and methods: In this study, 30 controlled diabetic patients needing implants in the mandibular posterior region were divided into two groups, that is, group I—patients with normal serum ALP and group II—patients with raised serum ALP. Each individual was rehabilitated with one implant following a nonfunctional immediate loading protocol. Implant stability in each individual was assessed by measuring implant stability quotient (ISQ) values. GCF/PICF samples were collected to evaluate the level of ALP. Both parameters were evaluated at baseline, 1, and 3 months postimplant placement, and the resulting values were compared using analysis of variance (ANOVA) and post hoc Bonferroni test within the group, and unpaired t-test was used for comparison between the two groups. The correlation between the two parameters was determined using Pearson’s correlation coefficient (r) test. Results: In group I patients with normal serum ALP, the mean ALP in GCF/PICF and ISQ values at baseline was 685.19 IU/L and 72.53; at 1 month, were 608.08 IU/L and 68.73; at 3 months, were 766.26 IU/L and 79.33, respectively. In group II patients with raised serum ALP, the mean ALP in GCF/PICF and ISQ values at baseline were 1042.75 IU/L and 72.40; at 1 month, were 932.75 IU/L and 65.07; at 3 months, were 1111.73 IU/L and 76.80, respectively. A significant difference was seen in GCF/PICF ALP values between the two groups, whereas nonsignificant difference was observed in ISQ values between group I and group II. Conclusion: No direct correlation was found between implant stability and GCF/PICF ALP in patients with normal serum ALP, and a negative correlation (with an increase in GCF/PICF ALP values, there was a corresponding decrease in the ISQ values) was found in patients with raised serum ALP at different time intervals. Keywords: Alkaline phosphatase, Biomarker, Dental implants, Diabetes, Implant stability.