Faculty & Staff
Dr. Jyothi S Prabhu
Professor and Head
- Overview
- Projects
- Publications
- Other Contributions
I am a physician-scientist trained in clinical pathology and molecular medicine, with over twenty years of experience in translational oncology research. My work has primarily focused on understanding the molecular basis of breast cancer in Indian patients, with particular emphasis on hormone receptor signalling, tumour microenvironment interactions, and mechanisms of therapeutic resistance.
I currently lead the Division of Molecular Medicine and coordinate multidisciplinary research programs involving clinicians, pathologists, molecular biologists, and data scientists. A significant part of my work has involved building and maintaining a longitudinal breast cancer cohort with integrated biospecimen repositories, enabling systematic investigation of clinical and molecular determinants of disease in Indian women.
My research has explored several aspects of breast cancer biology, including functional characterisation of estrogen receptor signalling, mechanisms underlying chemoresistance, and the distinct biology of breast cancer in young and postpartum women. More recently, my group has been applying genomic and spatial profiling approaches to understand tumour–immune interactions and their relevance to treatment response.
In parallel, I remain interested in developing cost-effective molecular diagnostic approaches, including liquid biopsy–based assays that could be implemented in routine clinical practice.
Qualification/ Education
- 2011 - 2015; PhD - Molecular Medicine
St. John’s Medical College , Rajiv Gandhi University of Health Sciences - 1998 - 2000; Diploma in Clinical Pathology (DCP)
Bangalore Medical College, Rajiv Gandhi University of Health Sciences - 1989 - 1995, Medicine
MRMC, Gulbarga University
Experience
- Professor
St. John’s Research Institute
2024 - till date
Bangalore, India - Associate Professor
St. John’s Research Institute
2016 - 2024
Bangalore, India - Assistant Professor
St. John’s Research Institute
2007 - 2016
Bangalore, India - Pathologist – Incharge of Molecular Pathology Laboratory
Triesta Sciences
2004 - 2007
Bangalore, India - Research Associate
National Institute for Research in Reproductive Health
2003 - 2004
Mumbai, India - Pathologist
Inlaks Hospital
2002 - 2003
Mumbai, India - Clinical Pathologist
Jivraj Mehtha Hospital
2000 - 2001
Ahmedabad, India
Areas of interest
Cohort and biorepository building; Integration of clinical and molecular Pathology; Breast cancer gene expression profiling; Patient clinical follow up; Characterization of intratumor genetic heterogeneity in breast cancers.
Field of Expertise
- Development of a longitudinal breast cancer cohort
- Functional characterization of estrogen receptor signalling
- Mechanisms of therapy resistance
- Breast cancer in young and postpartum women
- Development of low-cost mol
Fellowship & Membership
- Indian Association of Pathologists and Microbiologists
- European Society for Medical Oncology (ESMO)
- Indian Cancer Genome Atlas (ICGA) Foundation
- Molecular Pathologists Association of India
- Professor
St. John’s Research Institute
2024 - till date
Bangalore, India - Associate Professor
St. John’s Research Institute
2016 - 2024
Bangalore, India - Assistant Professor
St. John’s Research Institute
2007 - 2016
Bangalore, India - Pathologist – Incharge of Molecular Pathology Laboratory
Triesta Sciences
2004 - 2007
Bangalore, India - Research Associate
National Institute for Research in Reproductive Health
2003 - 2004
Mumbai, India - Pathologist
Inlaks Hospital
2002 - 2003
Mumbai, India - Clinical Pathologist
Jivraj Mehtha Hospital
2000 - 2001
Ahmedabad, India
Cohort and biorepository building; Integration of clinical and molecular Pathology; Breast cancer gene expression profiling; Patient clinical follow up; Characterization of intratumor genetic heterogeneity in breast cancers.
No groups and associations specified.
EPHA2-Ephrin-B1 cis-interaction drives an oncogenic reverse signaling, leading to the recurrence of oral cancer
Reshma Raj R, Nandini Datta, Soumya Krishnan U, Geetha Shanmugam, Jiss Maria Louis, Ravichandran Damodaran Jeyaram, Keshava K. Datta, Harsha Gowda, Meghna Sarkar, Madhumathy G. Nair, Jyothy S. Prabhu, Hafsa Shabeer, Balagopal P. G, Thameem A, Alan Jose, Vishnu Sunil Jaikumar & Tessy Thomas Maliekal Postpartum breast cancer as a distinct oncologic entity: linking physiological tissue remodelling to tumor biology and clinical translation
Vidya P. Nimbalkar, Snijesh V. P., Akash Dash, Meenakshi Jothikumar, Anjaney J. Pandey, P. S. Hari, Aruna Korlimarla, Sabarinathan Radhakrishanan & Jyothi S. Prabhu The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms
Mohammad Nafees Ansari ,Somesh K. Jha ,Ali Khan ,Kajal Rajput,Nishant Pandey,Dolly Jain,Rajeshwari Tripathi,Nihal Medatwal,Pankaj Sharma,Sudeshna Datta,Animesh Kar,Trishna Pani,Sk Asif Ali,Kaushavi Cholke,Kajal Rana,Valiya P. Snijesh,Geetashree Mukherjee,Suryanarayana V. S. Deo,Soumen Basak,Ashutosh Mishra,Jyothi S. Prabhu,Arnab Mukhopadhyay,Avinash Bajaj ,Ujjaini Dasgupta Role of intratumoral heterogeneity in metastatic progression and drug resistance
Neeha Sinai Borker, Jyothilakshmi Sajimon, Seemadri Subhadarshini, Rifat Aara, Mohit Kumar Jolly, Jyothi S. Prabhu & Radhika Nair Repurposing statins in combination therapy for effective ablation of metastatic breast cancer
Rifat Aara, Neeha Sinai Borker, Jyothilakshmi Sajimon, Seemadri Subhadarshini , Snijesh VP, Vidya P. Nimbalkar, Manju Moorthy, Archana P. Thankamony, Athul Krishnan R , Mohit Kumar Jolly, Jyothi S. Prabhu, Radhika Nair Spatial profiling reveals unique immune microenvironment in premenopausal triple-negative breast cancer associated with therapy response
Vidya P. Nimbalkar, V. P. Snijesh, Savitha Rajarajan, C. E. Anupama, S. Mahalakshmi, Annie Alexander, Deshica Dechamma, Manju Moorthy, Gopalakrishna Ramaswamy, Rakesh Ramesh, B. S. Srinath & Jyothi S. Prabhu Therapeutic vulnerabilities in triple negative breast cancer: Stem-like traits explored within molecular classification
Peng Huang, Xi Zhang , Jyothi S. Prabhu, Vijay Pandey Increased prevalence of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer
Sahoo S, Ramu S, Nair MG, Pillai M, San Juan BP, Milioli HZ, Mandal S, Naidu CM, Mavatkar AD, Subramaniam H, Neogi AG, Chaffer CL, Prabhu JS, Somarelli JA, Jolly MK. Elucidating the Role of MicroRNA-18a in Propelling a Hybrid Epithelial–Mesenchymal Phenotype and Driving Malignant Progression in ER-Negative Breast Cancer – Cells
Madhumathy G. Nair 1, Apoorva D. Mavatkar 1, Chandrakala M. Naidu 1, Snijesh V. P, Anupama C. E. , Savitha Rajarajan , Sarthak Sahoo , Gayathri Mohan , Vishnu Sunil Jaikumar , Rakesh S. Ramesh , Srinath B. S. , Mohit Kumar Jolly , Tessy Thomas Maliekal and Jyothi S. Prabhu Premenopausal women with breast cancer in the early post-partum period show molecular profiles of invasion and are associated with poor prognosis
Vidya P Nimbalkar, VP Snijesh, Savitha Rajarajan, Annie Alexander, Rohini Kaluve, Rakesh Ramesh, BS Srinath, Jyothi S Prabhu BRCA1 expression, its correlation with clinicopathological features, and response to neoadjuvant chemotherapy in high-grade serous ovarian cancer
Akkamahadevi Patil, Sharada Patil, C. E. Anupama, Savitha Rajarajan, Vidya P. Nimbalkar, Usha Amirtham, G. Champaka, M. N. Suma, Geetha V. Patil, Ashwini Nargund, V. R. Pallavi, Linu Jacob, C. S. Premalatha, Jyothi S. Prabhu An androgen receptor regulated gene score is associated with epithelial to mesenchymal transition features in triple negative breast cancers
Rajarajan S, Snijesh VP, Anupama CE, Nair MG, Mavatkar AD, Naidu CM, Patil S, Nimbalkar VP, Alexander A, Pillai M, Jolly MK, Sabarinathan R, Ramesh RS, Bs S, Prabhu JS Estimation of ALU Repetitive Elements in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer
Nair MG, Ramesh RS, Naidu CM, Mavatkar AD, V P S, Ramamurthy V, Somashekaraiah VM, C E A, Raghunathan K, Panigrahi A, Das M, Dhar SK, Prabhu JS Cell State Transitions and Phenotypic Heterogeneity in Luminal Breast Cancer Implicating MicroRNAs as Potential Regulators
Richard V, Nair MG, Jaikumar VS, Jones S, Prabhu JS, Kerin MJ The dynamic tumor-stromal crosstalk: implications of 'stromal-hot' tumors in the process of epithelial-mesenchymal transition in breast cancer
Mavatkar AD, Naidu CM, Prabhu JS, Nair MG Premenopausal women with breast cancer in the early post-partum period show molecular profiles of invasion and are associated with poor prognosis
Vidya P. Nimbalkar , V. P. Snijesh, Savitha Rajarajan, Annie Alexander,Rohini Kaluve,Rakesh Ramesh, B. S. Srinath,Jyothi S. Prabhu Effect of a Novel Sugar Blend on Weight and Cardiometabolic Health among Healthy Indian Adults: A Randomized, Open-Label Study
Srinath Aswathiah , Sunil Kumar Prabhu , Ramanna Lingaiah , Anusha Ramanna , Jyothi S. Prabhu , Shashi Kishor Pankaj , Arti Mehta , Arohi Bapna and Govindarajan Raghavan Comprehensive characterization of immune landscape of Indian and Western triple negative breast cancers
Korlimarla A, Ps H, Prabhu J, Ragulan C, Patil Y, Vp S, Desai K, Mathews A, Appachu S, Diwakar RB, Bs S, Melcher A, Cheang M, Sadanandam A miR-18a Mediates Immune Evasion in ER-Positive Breast Cancer through Wnt Signaling
Nair MG, D A, M C, Vp S, Patil S, Ce A, Mukherjee G, Kumar RV, Prabhu JS, Ts S CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors
Swati Priya , Ekjot Kaur , Swati Kulshrestha , Awadhesh Pandit , Isabelle Gross , Nitin Kumar , Himanshi Agarwal , Aamir Khan , Radhey Shyam , Prakash Bhagat, Jyothi S. Prabhu , Perumal Nagarajan , S. V. S. Deo , Avinash Bajaj , Jean-Noël Freund , Arnab Mukhopadhyay and Sagar Sengupta NGS-based profiling of key cancer genes in Indian triple-negative breast cancer patients reinforces molecular heterogeneity of the disease
Nandini A Sahasrabuddhe, Aruna Korlimarla, Madhura Kulkarni, Vinay Kusuma, Jyothi S Prabhu, Santosh Dixit, Chetan Deshmukh, T S Sridhar, Aditya Phatak, Chaitanyananda Koppiker Gender disparity in COVID-19: Role of sex steroid hormones
Anuja Lipsa , Jyothi S Prabhu Expression of HER2 and EGFR Proteins in Advanced Stage High-grade Serous Ovarian Tumors Show Mutual Exclusivity
Julian Crasta, Gayatri Ravikumar, Savitha Rajarajan, Sumangala Gali, Kiran A Kulkarni, Elizabeth Vallikad, Jyoti Prabhu High expression of ACE2 in HER2 subtype of breast cancer is a marker of poor prognosis
Nair MG, Prabhu JS, Ts S Pre-Menopausal Women With Breast Cancers Having High AR/ER Ratios in the Context of Higher Circulating Testosterone Tend to Have Poorer Outcomes
Rajarajan S, Korlimarla A, Alexander A, Anupama CE, Ramesh R, Srinath BS, Sridhar TS, Prabhu JS miRNAs: Critical mediators of breast cancer metastatic programming
Nair MG, Somashekaraiah VM, Ramamurthy V, Prabhu JS, Sridhar TS Geographic Information System enabled dengue surveillance system in south zone, Bangalore city: A pilot study.
Naveen Ramesh, Venkatesh Thimmaiah, Shivkumar Mallaiah, Anasuya Kandaswamy Identification of colorectal cancers with defective DNA damage repair by immunohistochemical profiling of mismatch repair proteins, CDX2 and BRCA1
Savitha Rajarajan, Anupama C.Ε, Betsy Jose, Marjorie Correa, Sagar Sengupta, Jyothi S. Prabhu miR-18a activates Wnt pathway in ER-positive breast cancer and is associated with poor prognosis
Nair MG, Prabhu JS, Korlimarla A, Rajarajan S, P S H, Kaul R, Alexander A, Raghavan R, B S S, T S S CD15 as a marker of fetoplacental endothelial immaturity in IUGR placentas
Gayatri Ravikumar, Julian Crasta, Jyothi S. Prabhu, Tinku Thomas, Pratibha Dwarkanath, Annamma Thomas, Anura V. Kurpad, Tirumalai Srinivas Sridhar The Impact of Breast Cancer on the Patient and the Family in Indian Perspective
Annie Alexander , Rohini Kaluve , Jyothi S Prabhu , Aruna Korlimarla , B S Srinath , Suraj Manjunath , Shekar Patil , K S Gopinath , T S Sridhar The Role of Circulating MicroRNA in the Regulation of Beta Cell Function and Insulin Resistance among Indians with Type 2 Diabetes
S. Sucharita, V. Ashwini. J. S. Prabhu, S. T. Avadhany, V. Ayyar, G. Bantwal Eccentric placentae have reduced surface area and are associated with lower birth weight in babies small for gestational age
G. Ravikumar , J. Crasta , J. S. Prabhu , T. Thomas , P. Dwarkanath , A. Thomas , T. S. Sridhar and A. V. Kurpad HR+HER2- breast cancers with growth factor receptor-mediated EMT have a poor prognosis and lapatinib downregulates EMT in MCF-7 cells
Krisha Desai , Radhika Aiyappa , Jyothi S Prabhu , Madhumathy G Nair , Patrick Varun Lawrence , Aruna Korlimarla , Anupama Ce , Annie Alexander , Rohini S Kaluve , Suraj Manjunath , Marjorrie Correa , B S Srinath , Shekhar Patil , Anjali Kalamdani , Msn Prasad , T S Sridhar Dissecting the Biological Heterogeneity within Hormone Receptor Positive HER2 Negative Breast Cancer by Gene Expression Markers Identifies Indolent Tumors within Late Stage Disease
Prabhu JS, Korlimarla A, Anupama CE, Alexander A, Raghavan R, Kaul R, Desai K, Rajarajan S, Manjunath S, Correa M, Raman R, Kalamdani A, Prasad M, Patil S, Gopinath KS, Srinath BS, Sridhar TS. Analysis of Clinico-Pathological Characteristics of Indian Breast CancersShows Conservation of Specific Features in the Hormone Receptor Sub-Types
Geetashree Mukherjee, KC Lakshmaiah, M Vijayakumar, Jyothi S Prabhu, Deepthi Telikicherla, TS Sridhar and Rekha V Kumar Identification of BRCA1 Deficiency Using Multi-Analyte Estimation of BRCA1 and Its Repressors in FFPE Tumor Samples from Patients with Triple Negative Breast Cancer
Korlimarla A, Prabhu JS, Remacle J, Rajarajan S, Raja U, C E A, Srinath BS, Manjunath S, K S G, Correa M, M S N P, Sridhar TS Data on alteration of hormone and growth factor receptor profiles over progressive passages of breast cancer cell lines representing different clinical subtypes
Nair MG, Desai K, Prabhu JS, Hari PS, Remacle J, Sridhar TS β3 integrin promotes chemoresistance to epirubicin in MDA-MB-231 through repression of the pro-apoptotic protein, BAD
Nair MG, Desai K, Prabhu JS, Hari PS, Remacle J, Sridhar TS High expression of integrin β6 in association with the Rho-Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers
Desai K, Nair MG, Prabhu JS, Vinod A, Korlimarla A, Rajarajan S, Aiyappa R, Kaluve RS, Alexander A, Hari PS, Mukherjee G, Kumar RV, Manjunath S, Correa M, Srinath BS, Patil S, Prasad MS, Gopinath KS, Rao RN, Violette SM, Weinreb PH, Sridhar TS Separate Quality-Control Measures Are Necessary for Estimation of RNA and Methylated DNA from Formalin-Fixed, Paraffin-Embedded Specimens by Quantitative PCR
Korlimarla A, Prabhu JS, Anupama CE, Remacle J, Wahi K, Sridhar TS A Majority of Low (1-10%) ER Positive Breast Cancers Behave Like Hormone Receptor Negative Tumors
Prabhu JS, Korlimarla A, Desai K, Alexander A, Raghavan R, Anupama C, Dendukuri N, Manjunath S, Correa M, Raman N, Kalamdani A, Prasad M, Gopinath KS, Srinath BS, Sridhar TS Identification of a non-canonical nuclear localization signal (NLS) in BRCA1 that could mediate nuclear localization of splice variants lacking the classical NLS
Aruna Korlimarla, Lekhana Bhandary, Jyothi S Prabhu, Hema Shankar, Hari Sankaranarayanan, Pravin Kumar, Jose Remacle, Dipa Natarajan, T S Sridhar The epigenetic silencing of the estrogen receptor (ER) by hypermethylation of the ESR1 promoter is seen predominantly in triple-negative breast cancers in Indian women
Prabhu JS, Wahi K, Korlimarla A, Correa M, Manjunath S, Raman N, Srinath BS, Sridhar TS Estrogen Receptor Negative Breast Cancer in India: Do We Really Have Higher Burden of this Subtype?
Suraj Manjunath, Jyothi S Prabhu, Rohini Kaluve, Marjorie Correa, T S Sridhar Gene-specific methylation: potential markers for colorectal cancer
Jyothi S Prabhu , Aruna Korlimarla, Arindam Banerjee, Shivangi Wani, Payal K, Rashmita Sahoo qRT-PCR Compliments Immunohistochemistry In Archival Breast Cancer Samples
PRABHU J S , WANI S , KORLIMARLA A, PAYAL K., VICTOR J M , ANAND A, SAHOO R Assessment of microsatellite instability in colorectal carcinoma at an Indian center
Vijay Pandey, Jyothi S. Prabhu, Payal K., Veena Rajan, C. Deepak, Shubhada Barde, P. Jagannath, Anita Borges & Sridhar T. S.