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Infectious Diseases
- Introduction to Division
- Key Personnel
- Projects
- Publications
- Activities & Events
- Careers
- Focus Areas
- Resources
Infectious Diseases
The Infectious Disease Unit houses Research in immunological and epidemiological aspects of bacterial, viral and mycobacterial infections. The projects network with clinical departments of St. John’s Medical College and Hospital and few extra-mural institutions. The laboratory in the unit handles molecular biology in the realm of research and diagnostic services for the hospital. A level 3 containment facility enables work in Tuberculosis and other infectious diseases requiring such a facility. A bio repository unit facilitates storage of various kinds of clinical samples such as peripheral blood cells, plasma, DNA extracts, bacterial cultures, etc. at temperatures of -20deg C, -80deg C and in liquid nitrogen (ether-phase).
The Division of Infectious Diseases focuses on the biological, immunological and epidemiological aspects of viral, bacterial and parasitic diseases of public health importance. The lab is currently working on Dengue, HIV, Tuberculosis and Malaria both from the hospital and community setting.
Key Personnel
Unit Head
Professor & Head
Professor & Head / MicrobiologyDr. Mary Dias currently holds the position of Professor in the Department of Microbiol...
Core Staff
| S.I. No | Project Title | Project Lead | Year of Initiation |
|---|---|---|---|
| 1 | C-CAMP InDx CoE – Validation centre | Dr. Mary Dias, Dr. Mamatha. V | 2023 |
| 2 | Biomarker signatures for diagnosis for tuberculosis | Dr. Mary Dias | 2018 |
| S.I. No | Title | Authors | Journal Name | Publication Year |
|---|---|---|---|---|
| 1 | Risk factors for recognized and unrecognized SARS-CoV-2 infection: a seroepidemiologic analysis of the Prospective Urban Rural Epidemiology (PURE) study | Leong DP, Loeb M, Mony PK, Rangarajan S, Mushtaha M, Miller MS, Dias M, Yegorov S, V M, Telci Caklili O, Temizhan A, Szuba A, Abat MEM, Mat-Nasir N, Diaz ML, Khansaheb H, Lopez-Jaramillo P, Duong M, Teo KK, Poirier P, Oliveira G, Avezum Á, Yusuf S | Risk factors for recognized and unrecognized SARS-CoV-2 infection | 2024 |
| 2 | BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways | Ahmed A, Tripathi H, van Meijgaarden KE, Kumar NC, Adiga V, Rakshit S, Parthiban C, Eveline J S, D'Souza G, Dias M, Ottenhoff THM, Netea MG, Joosten SA, Vyakarnam A | Iscience, 2023 | 2023 |
| 3 | Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians | Rakshit S, Babji S, Parthiban C, Madhavan R, Adiga V, J SE, Chetan Kumar N, Ahmed A, Shivalingaiah S, Shashikumar N, V M, Johnson AR, Ramesh N, B RG, Asokan M, Mayor S, Kang G, D'souza G, Dias M, Vyakarnam A | NPJ Vaccines. 2023 | 2023 |
| 4 | Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences | Sankaradoss A, Jagtap S, Nazir J, Moula SE, Modak A, Fialho J, Iyer M, Shastri JS, Dias M, Gadepalli R, Aggarwal A, Vedpathak M, Agrawal S, Pandit A, Nisheetha A, Kumar A, Bordoloi M, Shafi M, Shelar B, Balachandra SS, Damodar T, Masika MM, Mwaura P, Anzala O, Muthumani K, Sowdhamini R, Medigeshi GR, Roy R, Pattabiraman C, Krishna S, Sreekumar E. | Molecular Therapy, 2022 | 2022 |
| 5 | Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults | Rakshit S, Adiga V, Ahmed A, Parthiban C, Chetan Kumar N, Dwarkanath P, Shivalingaiah S, Rao S, D'Souza G, Dias M, Maguire TJA, Doores KJ, Zoodsma M, Geckin B, Dasgupta P, Babji S, van Meijgaarden KE, Joosten SA, Ottenhoff THM, Li Y, Netea MG, Stuart KD, De Rosa SC, McElrath MJ, Vyakarnam A | Frontiers in immunology, 2022 | 2022 |
| 6 | A century of BCG: Impact on tuberculosis control and beyond | Ahmed A, Rakshit S, Adiga V, Dias M, Dwarkanath P, D'Souza G, Vyakarnam A | Immunological reviews, 2021 | 2021 |
| 7 | Molecular detection of virulence markers to identify diarrhoeagenic Escherichia coli isolated from Mula-Mutha river, Pune District, India | Namachivayam SR, Dhawde RR, Macaden RS, Dias M, Birdi TJ. | Journal of Environmental Science and Health, Part A, 2021 | 2021 |
| 8 | Innate Immune Cytokine Profiling and Biomarker Identification for Outcome in Dengue Patients | Pradeep SP, Hoovina Venkatesh P, Manchala NR, Vayal Veedu A, Basavaraju RK, Selvasundari L, Ramakrishna M, Chandrakiran Y, Krishnamurthy V, Holigi S, Thomas T, Ross CR, Dias M, Satchidanandam V | Frontiers in Immunology, 2021 | 2021 |
| 9 | The Evolution of Regulatory Elements in the Emerging Promoter-Variant Strains of HIV-1 Subtype C | Bhange D, Prasad N, Singh S, Prajapati HK, Maurya SP, Gopalan BP, Nadig S, Chaturbhuj D, Jayaseelan B, Dinesha TR, Ahamed SF, Singh N, Brahmaiah A, Mehta K, Gohil Y, Balakrishnan P, Das BK, Dias M, Gangakhedkar R, Mehendale S, Paranjape RS, Saravanan S, Shet A, Solomon SS, Thakar M, Ranga U | Frontiers in microbiology, 2021 | 2021 |
| 10 | Using data from 'visible' populations to estimate the size and importance of 'hidden' populations in an epidemic: A modelling technique | Foss AM, Prudden HJ, Mitchell KM, Pickles M, Washington R, Phillips AE, Alary M, Boily MC, Moses S, Watts CH, Vickerman PT | National Library of Medicine | 2020 |
| 11 | Is a differentiated care model needed for patients with TB? A cohort analysis of risk factors contributing to unfavourable outcomes among TB patients in two states in South India | Washington R, Potty RS, Rajesham A, Seenappa T, Singarajipura A, Swamickan R, Shah A, Prakash KH, Kar A, Kumaraswamy K, Prarthana BS, Maryala BK, Sushma J, Dasari R, Shetty B, Panibatla V, Mohan HL, Becker M | National Library of Medicine | 2020 |
| 12 | Plasma metabolomic study in perinatally HIV-infected children using 1H NMR spectroscopy reveals perturbed metabolites that sustain during therapy | Kaur S U, Oyeyemi BF, Shet A, Gopalan BP, D H, Bhavesh NS, Tandon R | National Library of Medicine | 2020 |
| 13 | High frequency of exon 20 S768I EGFR mutation detected in malignant pleural effusions: A poor prognosticator of NSCLC | George D'Souza, Chirag Dhar, Vishal Kyalanoor, Lokendra Yadav, Mugdha Sharma , Mohammad Nawaz S, Sweta Srivastava | Cancer Rep (Hoboken) . | 2020 |
| 14 | Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes | Britto CD, Mathias S, Bosco A, Dyson ZA, Dougan G, Raveendran S, Abin VL, Jose S, Nagaraj S, Holt KE, Pollard AJ | National Library of Medicine | 2020 |
| 15 | Moraxella catarrhalis: A Cause of Concern with Emerging Resistance and Presence of BRO Beta-Lactamase Gene-Report from a Tertiary Care Hospital in South Indi | Raveendran S, Kumar G, Sivanandan RN, Dias M | National Library of Medicine | 2020 |
| 16 | Viral evolution in the cell-associated HIV-1 DNA during early ART can lead to drug resistance and virological failure in children | Gopalan BP, D'Souza RR, Rajnala N, Arumugam K, Dias M, Ranga U, Shet A | National Library of Medicine | 2019 |
| 17 | Tuberculosis notification in a private tertiary care teaching hospital in South India: a mixed-methods study | Siddaiah A, Ahmed MN, Kumar AMV, D'Souza G, Wilkinson E, Maung TM, Rodrigues R | National Library of Medicine | 2019 |
| 18 | Evidence for highly variable, region-specific patterns of T-cell epitope mutations accumulating in Mycobacterium tuberculosis strains | Ramaiah A, Nayak S, Rakshit S, Manson AL, Abeel T, Shanmugam S, Sahoo PN, John AJUK, Sundaramurthi JC, Narayanan S, D'Souza G, von Hoegen P, Ottenhoff THM, Swaminathan S, Earl AM, Vyakarnam A | National Library of Medicine | 2019 |
| 19 | Analysis of dengue specific memory B cells, neutralizing antibodies and binding antibodies in healthy adults from India | Gunisetty S, Nayak K, Chandra Rai R, Chawla Y, Reddy ES, Aggarwal C, Maheshwari D, Panda H, Ansari NA, Singh P, Kaur M, Dixit K, Sharma P, Bhatnagar P, Priyamvada L, Bhaumik SK, Ahamed SF, Vivek R, Ray P, Shet A, Coshic P, Lodha R, Kabra SK, Afroze D, Yousuf A, Ahmed R, Murali-Krishna K, Chandele A | National Library of Medicine | 2019 |
| 20 | Analysis of dengue specific memory B cells, neutralizing antibodies and binding antibodies in healthy adults from India | Gunisetty S, Nayak K, Chandra Rai R, Chawla Y, Reddy ES, Aggarwal C, Maheshwari D, Panda H, Ansari NA, Singh P, Kaur M, Dixit K, Sharma P, Bhatnagar P, Priyamvada L, Bhaumik SK, Ahamed SF, Vivek R, Ray P, Shet A, Coshic P, Lodha R, Kabra SK, Afroze D, Yousuf A, Ahmed R, Murali-Krishna K, Chandele A | National Library of Medicine | 2019 |
| 21 | Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation | D'Souza RR, Gopalan BP, Rajnala N, Phetsouphanh C, Shet A | National Library of Medicine | 2019 |
| 22 | Emergence of new genotypes and lineages of dengue viruses during the 2012-15 epidemics in southern India | Ahamed SF, Rosario V, Britto C, Dias M, Nayak K, Chandele A, Kaja MK, Shet A | National Library of Medicine | 2019 |
| 23 | Circulating HLA-DR+CD4+ effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis | Ahmed A, Adiga V, Nayak S, Uday Kumar JAJ, Dhar C, Sahoo PN, Sundararaj BK, Souza GD, Vyakarnam A | National Library of Medicine | 2018 |
| 24 | Seasonal prevalence of antibiotic-resistant bacteria in the river Mula-Mutha, India | Dhawde R, Macaden R, Ghadge A, Birdi T | National Library of Medicine | 2018 |
| 25 | Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy | Hameed PS, Bharatham N, Katagihallimath N, Sharma S, Nandishaiah R, Shanbhag AP, Thomas T, Narjari R, Sarma M, Bhowmik P, Amar P, Ravishankar R, Jayaraman R, Muthan K, Subbiah R, Ramachandran V, Balasubramanian V, Datta S | National Library of Medicine | 2018 |
| 26 | Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children | Gjøen JE, Jenum S, Sivakumaran D, Mukherjee A, Macaden R, Kabra SK, Lodha R, Ottenhoff THM, Haks MC, Doherty TM, Ritz C, Grewal HMS | National Library of Medicine | 2017 |
| 27 | Sub-therapeutic nevirapine concentration during antiretroviral treatment initiation among children living with HIV: Implications for therapeutic drug monitoring | Gopalan BP, Mehta K, D'souza RR, Rajnala N, A K HK, Ramachandran G, Shet A | National Library of Medicine | 2017 |
| 28 | Host transcriptional responses following ex vivo re-challenge with Mycobacterium tuberculosis vary with disease status | Yu EA, John SH, Tablante EC, King CA, Kenneth J, Russell DG, Mehta S | National Library of Medicine | 2017 |
| 29 | Deep sequencing of near full-length HIV-1 genomes from plasma identifies circulating subtype C and infrequent occurrence of AC recombinant form in Southern India | Alampalli SV, Thomson MM, Sampathkumar R, Sivaraman K, U K J AJ, Dhar C, D Souza G, Berry N, Vyakarnam A | National Library of Medicine | 2017 |
| 30 | Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis | Rakshit S, Adiga V, Nayak S, Sahoo PN, Sharma PK, van Meijgaarden KE, Uk J AJ, Dhar C, Souza GD, Finak G, De Rosa SC, Ottenhoff THM, Vyakarnam A | National Library of Medicine | 2017 |
| 31 | Evaluation of a pan-serotype point-of-care rapid diagnostic assay for accurate detection of acute dengue infection | Vivek R, Ahamed SF, Kotabagi S, Chandele A, Khanna I, Khanna N, Nayak K, Dias M, Kaja MK, Shet A | National Library of Medicine | 2017 |
| 32 | Enhancing the sensitivity of Dengue virus serotype detection by RT-PCR among infected children in India | Ahamed SF, Vivek R, Kotabagi S, Nayak K, Chandele A, Kaja MK, Shet A | National Library of Medicine | 2017 |
| 33 | Unbiased Identification of Blood-based Biomarkers for Pulmonary Tuberculosis by Modeling and Mining Molecular Interaction Networks | Sambarey A, Devaprasad A, Mohan A, Ahmed A, Nayak S, Swaminathan S, D'Souza G, Jesuraj A, Dhar C, Babu S, Vyakarnam A, Chandra N | National Library of Medicine | 2016 |
| 34 | Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children | Jenum S, Dhanasekaran S, Ritz C, Macaden R, Doherty TM, Grewal HM; TB Trials Study Group | National Library of Medicine | 2016 |
| 35 | A step-wise approach towards introduction of an alcohol based hand rub, and implementation of front line ownership - using a, rural, tertiary care hospital in central India as a model | Sharma M, Joshi R, Shah H, Macaden R, Lundborg CS | National Library of Medicine | 2015 |
| 36 | Evaluation of a Community-Based HIV Preventive Intervention for Female Sex Workers in Rural Areas of Karnataka State, South India | Washington RG, Nath A, Isac S, Javalkar P, Ramesh BM, Bhattacharjee P, Moses S | National Library of Medicine | 2014 |
| 37 | Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles | Dhanasekaran S, Jenum S, Stavrum R, Ritz C, Kenneth J, Vaz M, Doherty TM, Grewal HM; TB Trials Study Group | National Library of Medicine | 2014 |
| 38 | The Frequencies of IFN?+IL2+TNF?+ PPD-Specific CD4+CD45RO+ T-Cells Correlate with the Magnitude of the QuantiFERON® Gold In-Tube Response in a Prospective Study of Healthy Indian Adolescents | Jenum S, Grewal HM, Hokey DA, Kenneth J, Vaz M, Doherty TM, Jahnsen FL; TB Trials Study Group | National Library of Medicine | 2014 |
| 39 | Detection of Carbapenem resistance genes and Cephalosporin, and Quinolone Resistance genes along with oqxAB gene in E. coli in hospital waste water: a matter of concern | Chandran SP, Diwan V, Tamhankar AJ, Joseph BV, Rosales-Klintz S, Mundayoor S, Lundborg CS, Macaden R | National Library of Medicine | 2014 |
| 40 | Exploring the population-level impact of antiretroviral treatment: the influence of baseline intervention context | Mishra S, Mountain E, Pickles M, Vickerman P, Shastri S, Gilks C, Dhingra NK, Washington R, Becker ML, Blanchard JF, Alary M, Boily MC; Strategic Epi-ART in India Modelling Team | National Library of Medicine | 2014 |
| 41 | Influence of Age and Nutritional Status on the Performance of the Tuberculin Skin Test and QuantiFERON®-TB Gold In-Tube in Young Children Evaluated for Tuberculosis in Southern India | Jenum S, Selvam S, Mahelai D, Jesuraj N, Cárdenas V, Kenneth J, Hesseling AC, Doherty TM, Vaz M, Grewal | National Library of Medicine | 2014 |
| 42 | Papulonecrotic tuberculid-clinicopathologic and molecular features of 12 Indian patients | Rajalakshmi Tirumalae , Inchara K Yeliur , Meryl Antony , Geojith George , John Kenneth | Papulonecrotic tuberculid-clinicopathologic and molecular features of 12 Indian patients | 2014 |
| 43 | Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management | Dhanasekaran S, Jenum S, Stavrum R, Wiker HG, Kenneth J, Vaz M, Doherty TM, Grewal HM; TB Trials Study Group | National Library of Medicine | 2014 |
| 44 | Micronutrients and Dengue | Ahmed S, Finkelstein JL, Stewart AM, Kenneth J, Polhemus ME, Endy TP, Cardenas W, Mehta S | National Library of Medicine | 2014 |
| 45 | Who mixes with whom among men who have sex with men? Implications for modelling the HIV epidemic in southern India | Mitchell KM, Foss AM, Prudden HJ, Mukandavire Z, Pickles M, Williams JR, Johnson HC, Ramesh BM, Washington R, Isac S, Rajaram S, Phillips AE, Bradley J, Alary M, Moses S, Lowndes CM, Watts CH, Boily MC, Vickerman P | National Library of Medicine | 2014 |
| 46 | Tuberculosis diagnostics in India: creating an ecosystem for innovation. | Engel N, Kenneth J, Pai M | National Library of Medicine | 2014 |
| 47 | Frequency and factors associated with carriage of multi-drug resistant commensal Escherichia coli among women attending antenatal clinics in Central India. | Pathak A, Chandran SP, Mahadik K, Macaden R, Lundborg CS | National Library of Medicine | 2013 |
| 48 | Identification of biomarkers for Mycobacterium tuberculosis infection and disease in BCG-vaccinated young children in Southern India | Dhanasekaran S, Jenum S, Stavrum R, Ritz C, Faurholt-Jepsen D, Kenneth J, Vaz M, Grewal HM, Doherty TM; TB Trials Study Group | National Library of Medicine | 2013 |
| 49 | Identification of biomarkers for Mycobacterium tuberculosis infection and disease in BCG-vaccinated young children in Southern India | Dhanasekaran S, Jenum S, Stavrum R, Ritz C, Faurholt-Jepsen D, Kenneth J, Vaz M, Grewal HM, Doherty TM; TB Trials Study Group | National Library of Medicine | 2013 |
| 50 | Qualitative study on perceptions of hand hygiene among hospital staff in a rural teaching hospital in India. | Joshi SC, Diwan V, Tamhankar AJ, Joshi R, Shah H, Sharma M, Pathak A, Macaden R, Stålsby Lundborg C | National Library of Medicine | 2012 |
| 51 | Identification of extended-spectrum b-lactamase and quinolone resistance genes in Escherichia-coli isolated from hospital wastewater from central India. | Diwan V, Chandran SP, Tamhankar AJ, Stålsby Lundborg C, Macaden R | National Library of Medicine | 2012 |
| 52 | Factors associated with carriage of multi-resistant commensal Escherichia coli among postmenopausal women in Ujjain, India. | Pathak A, Mahadik K, Sharma R, Marothi Y, Sharma M, Macaden R, Lundborg CS | National Library of Medicine | 2012 |
| 53 | High prevalence of extended-spectrum ?-lactamase-producing pathogens: results of a surveillance study in two hospitals in Ujjain, India. | Pathak A, Marothi Y, Kekre V, Mahadik K, Macaden R, Lundborg CS | National Library of Medicine | 2012 |
| 54 | Carbapenem resistance among Escherichia coli and Klebsiella pneumoniae in a tertiary care hospital in south India. | Nagaraj S, Chandran SP, Shamanna P, Macaden R | National Library of Medicine | 2012 |
| 55 | Host biomarkers of clinical relevance in tuberculosis : review of gene and protein expression studies. | John SH, Kenneth J, Gandhe AS | National Library of Medicine | 2011 |
| 56 | Efficacy of loop mediated isothermal amplification (LAMP) assay for the laboratory identification of Mycobacterium tuberculosis isolates in a resource limited setting. | Geojith G, Dhanasekaran S, Chandran SP, Kenneth J | National Library of Medicine | 2010 |
| 57 | Comparison of different standards for real-time PCR-based absolute quantification. | Dhanasekaran S, Doherty TM, Kenneth J; TB Trials Study Group | National Library of Medicine | 2010 |
| 58 | The expanding HIV-1 epidemic aggravates therapeutics and vaccine development programs in India. | Neogi U | National Library of Medicine | 2009 |
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