History:
In 1994, Dr. Prem Pais began work with cardio vascular disease research and set up the Clinical Epidemiology Research and Training Centre (CERTC) in the St. John’s Medical College. This later evolved to the Division of Clinical Research and Training (DCRT) and was integrated into the St. John’s Research Institute in 2004. Dr Denis Xavier joined the group in 1998.
Research Projects:
The Division of Clinical Research and Training (DCRT) designs and conducts, large national and international clinical trials and observational studies in cardiovascular disease (CVD), diabetes, oncology, nephrology and infectious diseases. Our collaboration includes over 240 Institutions in India and South Asia. To date we have or are conducting 67 large multi-centre projects and included over 160,400 participants.
Most of these are investigator-initiated studies funded by peer-reviewed grants and some are supported by Industry. Our studies have been published in leading journals including the Lancet, JAMA, NEJM, Nature Cardiovascular, American Heart Journal, Circulation, European Heart Journal, Indian Heart Journal, JAPI, IJMR etc. Click here for our publications.
Key Recognitions:
ICMR-Collaborating Centre of Excellence (CCoE)
We have been recently recognised as an ICMR Collaborating Centre of Excellence, one of 20 centres in India, to receive this honour in recognition of our three decades of work in cardiovascular disease prevention. The Director General of the ICMR mentioned that this is the highest honour biomedical scientists in India can get from the ICMR. Our mandate is to conduct high quality collaborative research and train individuals and institutions nationwide for better health. Click here for more details.
ICMR- Centres for Advanced Research (CAR)
We have been recognised by The Indian Council for Medical Research (ICMR) as a Centre for Advance Research (CAR) for the period 2024 to 2029. Dr. Denis Xavier is the Principal Investigator for the study titled “Impact, cost-effectiveness, and sustainability of a synergistic, multipronged, customized, low-cost intervention package (IP) to reduce cardiovascular disease (CVD) burden among diverse populations across India.
Over 5 years we will conduct the project in three steps – 1. Formative research to develop the interventions - systematic review, cross-sectional and a qualitative study followed by a DELPHI process. 2. A Cluster Randomized Controlled Trial 3. Policy level engagement and advocacy based on the results of the trial. The results will be disseminated through patient engagement activities and symposia. Click here for more details.
NIH –Centre of Excellence
We have been recognised as a Centre of Excellence by the National Institutes of Health (NIH) USA for the prevention and control of chronic disease (2009-2014). Over 5 years, we conducted 3 large multi-centre knowledge translation studies. These included primary (PREPARE) and secondary (SPREAD) prevention of ischemic heart disease and an observational study in strokes (INSPIRE). We also initiated several training programmes in Research methods and are now conducting 2 short courses every year. Dr Denis Xavier is the Principal Investigator.
Training:
Since 16 years we are conducting courses and workshops on clinical research methods for faculty and postgraduate students in medical colleges, personnel in government agencies, ethics committees and industry. Till date we have conducted 31 programs and about 2197 participants from 83 institutions in 45 cities across 12 countries have participated. Click here for more details.
Contribution and Future Focus:
Over almost 3 decades we have helped to understand the burden of ischemic heart disease and strokes across the country, its risk factors and treatments.Our new areas of focus include knowledge translation research in these areas as well as multi morbidity. We are currently evaluating interventions for self -care in chronic diseases, including optimal use of health technologies. Click here for a list of our projects.
Professor and Head, Department of Pharmacology, St. John's Medical CollegeEx-Vice Dean (PG), St. John's Medical Colle...
Division / Project : Clinical Research and TrainingDesignation :Assistant ProfessorFOGARTY – GLOCAL Fellow, Universit...
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Associate Professor (Pharmacology).Dr. Deepak Kamath teaches undergraduate Pharmacology and is a university registere...
Designation : Senior study coordinator Contact : preeti@sjri.res.in Education:2010 - 2011- Distance-Based Certificat...
| S.I. No | Title | Authors | Journal Name | Publication Year |
|---|---|---|---|---|
| 1 | Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial. | Michael Walsh, MD PhDa,b mwwalsh@mcmaster.ca ∙ David Collister, MD PhDa,c ∙ Martin Gallagher, MBChB PhDd,e ∙ Patrick B Mark, MBChB PhDf ∙ Janak R de Zoysa, MBChB MClinEdg,h ∙ Jessica Tyrwhitt, BSca ∙ Karthik Tennankore, MD MSci,j ∙ Gilmar Reis, MD PhDb,k ∙ Denis Xavier, MD PhDl ∙ Wen J Liu, MBChBm ∙ Li Zuo, MD PhDn ∙ Amanda Y Wang, MD PhDe,o,p ∙ Camilo Félix, MD PhDq ∙ Laura Sola, MDr ∙ Mustafa Arici, MD PhDs ∙ Russell Villanueva, MDt ∙ Vivekanand Jha, MD PhDu,v,w ∙ Dalton Précoma, MD PhDx ∙ Christian G Rabbat, MD MScb ∙ Sheik Sulthan Alavudeen, MDy ∙ Atiya R Faruqui, MD | The Lancet | 2025 |
| 2 | Influence of age on the association of vascular risk factors with acute stroke (INTERSTROKE): a case–control study | Catriona Reddin, Graeme J Hankey, Albertino Damasceno, Denis Xavier, Patricio Lopez-Jaramillo, Andrew Smyth, Salim Yusuf, Martin O’Donnell | The Lancet Health Longevity | 2025 |
| 3 | Effects of a hypotension-avoidance versus a hypertension-avoidance strategy on neurocognitive outcomes after noncardiac surgery | Maura Marcucci, Matthew TV Chan, Thomas W Painter, … Denis Xavier, Edith Fleischmann, Chew Yin Wang, Christian S Meyhoff, …PJ Devereaux | Annals of Internal Medicine | 2025 |
| 4 | The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol | Michael Walsh, David Collister, Martin Gallagher, … Denis Xavier,…Vivekanand Jha, Ron Wald, Amanda Y Wang, Atiya R Faruqui, Fei Yuan, Shun Fu Lee, Alena Kuptsova, Courtney Christou, PJ Devereaux | Canadian J Kidney Health and Disease | 2025 |
| 5 | Improving the clinical trial environment and infrastructure: moving from global resolution to action | Vasee Moorthy, Nandi Siegfried, John Amuasi, Jing Li, Michael Makanga, Karla Soares-Weiser, Sheamini Sivasampu, Denis Xavier, Faiez Zannad, Valerie Snewin | The Lancet Global Health | 2025 |
| 6 | Preoperative estimated glomerular filtration rate to predict cardiac events in major noncardiac surgery: a secondary analysis of two large international studies | Pavel S Roshanov, Michael W Walsh, .. Kate Leslie, Matthew TV Chan, Flavia K Borges, Chew Yin Wang, Denis Xavier, Miriam de Nadal, PJ Devereaux | British Journal of Anaesthesia | 2025 |
| 7 | Safety and efficacy of tranexamic acid in general surgery | Lily J Park, Maura Marcucci, Denis Xavier, Maria Jose Martinez-Zapata, ..PJ Devereaux | JAMA Surgery | 2025 |
| 8 | Preoperative estimated glomerular filtration rate to predict cardiac events in major noncardiac surgery: a secondary analysis of two large international studies | Pavel S Roshanov, Michael W Walsh, .. Kate Leslie, Matthew TV Chan, Flavia K Borges, Chew Yin Wang, Denis Xavier, Miriam de Nadal, PJ Devereaux | British Journal of Anaesthesia | 2025 |
| 9 | Effects of Aspirin in Primary Prevention of Cardiovascular (CV) Disease in People with Chronic Kidney Disease (CKD): Results of the TIPS3 Trial. | Johannes FE Mann, Philip Joseph, Peggy Gao, *Prem Pais*, *Denis Xavier*, Tony Dans, Patricio Lopez Jaramillo, Habib Gamra, Jessica Tyrwhitt, Salim Yusuf MO201 | Nephrology Dialysis Transplantation | 2025 |
| 10 | Blood pressure variability in acute stroke: Risk factors and association with functional outcomes at 1 month | Catriona Reddin, Robert Murphy, Graeme J Hankey, Xingyu Wang, Peter Langhorne, Shahram Oveisgharan, Denis Xavier, Conor Judge, … Andrew Smyth, Salim Yusuf | European Journal of Neurology | 2024 |
| 11 | Variations in the prevalence of atrial fibrillation, and in the strength of its association with ischemic stroke, in countries with different income levels: INTERSTROKE case-control study | Robert Murphy, Albertino Damasceno, Catriona Reddin, Graeme J Hankey, Helle K Iversen, Shahram Oveisgharan, Denis Xavier, Patricio Lopez Jamarillo, Xingyu Wang, Salim Yusuf | International Journal of Stroke | 2024 |
| 12 | Timing of Major Postoperative Bleeding Among Patients Undergoing Surgery | 202. Alex LE Halme, Pavel S Roshanov, Preetha George, Denis Xavier, HY Lai | JAMA Network Open | 2024 |
| 13 | Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case-control study | Xingyu Wang, Martin J O'Donnell, Allan Sniderman, Graeme J Hankey, Sumathy Rangarajan, Purnima Rao-Melacini, John Ferguson, Denis Xavier, Salim Yusuf | E Clinical Medicine | 2024 |
| 14 | Markers of Periodontal Disease and risk of Stroke: INTERSTROKE case-control study | Robert P Murphy, Graeme J Hankey, Conor Judge, Catriona Reddin, Peter Langhorne, Patricio López–Jaramillo, Charles Mondo, Denis Xavier, Xingyu Wang, Salim Yusuf, Martin O'Donnell | Journal of Stroke and Cerebrovascular Diseases | 2024 |
| 15 | Pre morbid sleep disturbance and its association with stroke severity: results from the international INTERSTROKE study. | Christine E Mc Carthy, Salim Yusuf, Conor Judge, John Ferguson, Graeme J Hankey, Shahram Oveis Gharan, Albertino Damasceno, Helle Klingenberg Iversen, Annika Rosengren, Okechukwu Ogah, Luísa Avezum, Patricio Lopez?Jaramillo, *Denis Xavier*, Xingyu Wang, Sumathy Rangarajan, Martin J O'Donnell. | European Journal of Neurology | 2024 |
| 16 | Carbonated Beverage, Fruit Drink, and Water Consumption and Risk of Acute Stroke: the INTERSTROKE Case-Control Study. | Andrew Smyth, Graeme J Hankey, Albertino Damasceno, Helle Klingenberg Iversen, Shahram Oveisgharan, Fawaz Alhussain, Peter Langhorne, *Dennis Xavier*, Patricio Lopez Jaramillo, Aytekin Oguz, Clodagh McDermott, Anna Czlonkowska, Fernando Lanas, Danuta Ryglewicz, Catriona Reddin, Xingyu Wang, Annika Rosengren, Salim Yusuf, Martin O’Donn | Journal of Stroke | 2024 |
| 17 | Cost effectiveness analysis of a fixed dose combination pill for primary prevention of cardiovascular disease from an individual participant data meta-analysis. | Andre Lamy, Wesley Tong, Philip Joseph, Peggy Gao, Mark D Huffman, Gholamreza Roshandel, Reza Malekzadeh, Patricio Lopez-Jaramillo, *Prem Pais*, *Denis Xavier*, Alvaro Avezum, Antonio L Dans, Habib Gamra, Salim Yusuf. | EClinicalMedicine | 2024 |
| 18 | Tea and coffee consumption and risk of acute stroke: The INTERSTROKE study. | Andrew Smyth, Graeme J Hankey, Peter Langhorne, Catriona Reddin, Danuta Ryglewicz, Annika Rosengren, *Dennis Xavier*, Michelle Canavan, Shahram Oveisgharan, Xingyu Wang, Patricio Lopez Jaramillo, Albertino Damasceno, Anna Czlonkowska, Helle Klingenberg Iversen, Fernando Lanas, Salim Yusuf, Martin O’Donnell. Publication Year : 2024 | International Journal of Stroke | 2024 |
| 19 | A sub-study of the POISE-3 randomized trial examined effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute. | Amit X Garg, Maura Marcucci, Meaghan S Cuerden, Jessica M Sontrop, Thomas W Painter, Vladimir Lomivorotov, Daniel I Sessler, Matthew TV Chan, Flavia K Borges, Kate Leslie, Emmanuelle Duceppe, Chirag R Parikh, Pavel Roshanov, María José Martínez-Zapata, Chew Yin Wang, *Denis Xavier*, Jessica Spence, Thomas Van Helder, Richard Whitlock, Pj Devereaux, et al… | Kidney International | 2024 |
| 20 | Association of Vascular Risk With Severe vs Non-Severe Stroke: An Analysis of the INTERSTROKE Study | Catriona Reddin, Michelle Canavan, Graeme J Hankey, Shahram Oveisgharan, Peter Langhorne, Xingyu Wang, Annika Rosengren, *Denis Xavier*, Salim Yusuf, Martin J O'Donnell, et al… INTERSTROKE investigators | Neurology | 2024 |
| 21 | Effects of a polypill, aspirin or both on cognitive and functional outcomes | Bosch JJ, O’Donnel, Gao P, Joseph P, *Pais P*, *Xavier D*, Dans A, Lopez J & Yusuf S | JAMA Neurology | 2023 |
| 22 | Vitamin D supplementation and adverse skeletal and non-skeletal outcomes in individuals at increased cardiovascular risk: Results from the International Polycap Study (TIPS-3) | P Joseph, *P Pais*, P Gao, K Teo, *D Xavier*, P Lopez-Jaramillo, K Yusoff, A Santoso, H Gamra, SH Talukder, S Yusuf et al…. | Nutrition, Metabolism and Cardiovascular Diseases | 2023 |
| 23 | An Observational Multi-centric COVID-19 Sequelae Study among Health Care Workers | Ajay Kumar Shukla, Shubham Atal, Aditya Banerjee, Ratinder Jhaj, Sadasivam Balakrishnan, Preeta Kaur Chugh, *Denis Xavier*, *Atiya Faruqui*, *Aakanksha Singh*, et al… | The Lancet Regional Health-Southeast Asia | 2023 |
| 24 | Secondary prevention with a structured semi-interactive stroke prevention package in INDIA (SPRINT INDIA) | Jeyaraj Durai Pandian, Mahesh Pundlik Kate, Padmavathyamma Narayanapillai Sylaja, Dheeraj, *Prem Pais*, *Denis Xavier*, et al…. | The Lancet Global Health | 2023 |
| 25 | Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study | Robert P Murphy, Catriona Reddin, Annika Rosengren, Conor Judge, Graeme J Hankey, … Albertino Damasceno, Denis Xavier, Alvaro Avezum, Xingyu Wang, Peter Langhorne, Salim Yusuf | Neurology | 2023 |
| 26 | POISE-3 Trial Investigators and Study Groups- ''Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery'' | Maura Marcucci, Thomas W Painter, David Conen, Vladimir Lomivorotov, Daniel I Sessler, Matthew TV Chan, Flavia K Borges, Kate Leslie, Emmanuelle Duceppe, María José Martínez-Zapata, Chew Yin Wang, Denis Xavier, Sandra N Ofori, Michael Ke Wang, et al... | Annals of Internal Medicine | 2023 |
| 27 | A randomized controlled trial evaluating a theory driven, complex intervention centered on task sharing and mobile health to improve selfcare and outcomes in heart failure – The PANACEA-HF RCT: Design and rationale | DY Kamath*, J Abdullakutty, BB Granger, S Kulkarni, *KB Bhuvana*, LJ Salazar, S Shifra, J Idiculla, J Narendra, K Varghese, *D Xavier*. | Cardiology Research and Practice | 2023 |
| 28 | Effects of aspirin on cardiovascular outcomes in patients with chronic kidney disease | Johannes FE Mann, Philip Joseph, Peggy Gao, Prem Pais, Jessica Tyrwhitt, Denis Xavier, Salim Yusuf et al | Kidney International | 2023 |
| 29 | Sleep Patterns and the Risk of Acute Stroke: Results from the INTERSTROKE International Case-Control Study | Christine Eileen Mc Carthy, Salim Yusuf, Conor Judge, Graeme J Hankey, Helle Klingenberg Iversen, Annika Rosengren, Alvaro Avezum, Patricio Lopez-Jaramillo, Denis Xavier | Neurology | 2023 |
| 30 | Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised Trials | Rustam Al-Shahi Salman, Jacqueline Stephen, Jayne F Tierney, Steff C Lewis, David E Newby, Adrian R Parry-Jones, Philip M White, Denis Xavier, Jackie Bosch | The Lancet Neurology | 2023 |
| 31 | Characteristics, clinical practice patterns and outcomes of strokes in India: INSPIRE-A multicentre prospective study | Denis Xavier*, Robert Murphy, *Prem Pais*, Jeyaraj Pandian, Sarma RK Gosala, Nandini Mathur, Dheeraj Khurana, R Sundararajan, Rajeev Gupta, Rajnish Joshi, Somesh Vanchilingam, PN Venkatarathanamma, Soaham Desai, Catriona Reddin, Martin O'Donnell, Salim Yusuf. | International Journal of Stroke | 2023 |
| 32 | Vitamin D supplementation and adverse skeletal and non-skeletal outcomes in individuals at increased cardiovascular risk: Results from the International Polycap Study (TIPS-3) | P Joseph, *P Pais*, P Gao, K Teo, *D Xavier*, P Lopez-Jaramillo, K Yusoff, A Santoso, H Gamra, SH Talukder, S Yusuf et al… | Nutrition, Metabolism and Cardiovascular Diseases | 2023 |
| 33 | Effects of a polypill, aspirin or both on cognitive and functional outcomes | Bosch JJ, O’Donnel, Gao P, Joseph P, *Pais P*, *Xavier D*, Dans A, Lopez J & Yusuf S | JAMA Neurology | 2023 |
| 34 | External applicability of the Effect of ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) trial: An analysis of patients with diabetes and coronary artery disease in the REduction of Atherothrombosis for Continued Health (REACH) registry. | Abtan J, Bhatt DL, Elbez Y, Ducrocq G, Goto S, Smith SC Jr, Ohman EM, Eagle KA, Fox K, Harrington RA, Leiter LA, Mehta SR, Simon T, Petrov I, Sinnaeve PR, *Pais P*, Lev E, Bueno H, Wilson P, Steg PG, on behalf of the REACH Registry Investigators | International Journal of Cardiology | 2022 |
| 35 | HbA1c Reduction in Dulaglutide-Treated Patients Irrespective of Duration of Diabetes, Microvascular Disease, and BMI: A Post Hoc Analysis From the REWIND Trial | Anita YM Kwan, Hertzel C Gerstein, Jan Basile, *Denis Xavier*, Juan M Maldonado, Sohini Raha, Manige Konig | Diabetes Care | 2022 |
| 36 | Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial. | Amit X Garg, Meaghan Cuerden, Richard Whitlock, Maria Wittmann, *Denis Xavier*, PJ Devereaux, Hector Aguado, Mohammed Amir, Emilie P Belley-Cote, Keyur Bhatt, Bruce M Biccard Michael McGillion, William McIntyre, Christian Meyhoff, Sandra Ofori, Thomas Painter, Pilar Paniagua, Chirag Parikh, Joel Parlow, Ameen Patel, Carisi Polanczyk, Toby Richards, Pavel Roshanov, et al. | Canadian Journal of Kidney Health and Disease | 2022 |
| 37 | Anger or emotional upset and heavy physical exertion as triggers of stroke: the INTERSTROKE study | Andrew Smyth, Martin O’Donnell, Graeme J Hankey, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Denis Xavier, Salim Yusuf | European Heart Journal | 2022 |
| 38 | The Anti-Coronavirus Therapy (ACT) trials: design, baseline characteristics, and challenges | Eikelboom J, Rangarajan S, Jolly SS, Belley-Cote EP, *Prem Pais*, *Xavier D*, Whitlock R, Beresh H, Lewis G, Xu L, Chan N, Bangdiwala S, Diaz R, et all | CJC open | 2022 |
| 39 | Tranexamic acid in patients undergoing noncardiac surgery | PJ Devereaux, Maura Marcucci, *Denis Xavier*, Jessica Vincent, John Eikelboom, Jessica Spence, Toby Richards, Tomas VanHelder, William McIntyre, Gordon Guyatt, Salim Yusuf, Kate Leslie, et al… | CJC open | 2022 |
| 40 | Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery | Maura Marcucci, Thomas W Painter, David Conen, Kate Leslie, Vladimir V Lomivorotov, Daniel Sessler, Matthew TV Chan, Flavia K Borges, , *Denis Xavier*, Ingrid Copland, Jessica Vincent, Gordon Guyatt, Emily Belley-Cote, Jessica Spence, William McIntyre, Salim Yusuf, PJ Devereaux, Et al | Trials | 2022 |
| 41 | Association of Psychosocial Stress With Risk of Acute Stroke | Catriona Reddin, Robert Murphy, Graeme J Hankey, Conor Judge, *Denis Xavier*, Annika Rosengren, John Ferguson, Salim Yusuf, Martin O’Donnell, Sumathy Rangaran, *Prem Pais*, Osamah Albaker, et al.. | JAMA Network Open | 2022 |
| 42 | Dulaglutide and cardiovascular and heart failure outcomes in patients with and without heart failure: a post-hoc analysis from the REWIND randomized trialDulaglutide and cardiovascular and heart failure outcomes in patients with and without heart failure: a post-hoc analysis from the REWIND randomized trial | Branch KRH, Dagenais GR, Avezum A, Basile J, Conget I, Cushman WC, Jansky P, Lakshmanan M, Lanas F, Leiter LA, *Pais P*, Pogosova N, Raubenheimer PJ, Ryden L, Shaw JE, Sheu WHH, Temelkova-Kurktschiev T, Bethe MA, Gerstein HC, Chinthanie R & Probstfiel JL. | European Journal of Heart Failure | 2022 |
| 43 | A novel kidney disease index reflecting both the albumin-to-creatinine ratio and estimated glomerular filtration rate, predicted cardiovascular and kidney outcomes in type 2 diabetes | Hertzel C Gerstein, Chinthanie Ramasundarahettige, Alvero Avezum, Jan Basile, Ignacio Conget, William C Cushman, Gilles R Dagenais, Edward Franek, Mark Lakshmanan, Fernando Lanas, Lawrence A Leiter, *Denis Xavier*, et al.. | Cardiovascular Diabetology | 2022 |
| 44 | Usability and feasibility assessment of a smartphone application (Suhriday) for heart failure self-care remote monitoring in an Indian tertiary health care setting: a pilot mixed-methods study | Bhuvana Kolar Bylappa 1, Deepak Y Kamath 2 3, Immaculate Sheela Josephine 3, Jabraan Shaikh 4, Anant Kamath 5, Preethi Rioniz 2, Shruthi Kulkarni 6, Kiron Varghese 4, Denis Xavier 2 3 | BMJ Open | 2022 |
| 45 | Vitamin D supplementation and adverse skeletal and non-skeletal outcomes in individuals at increased cardiovascular risk: results from the The International Polycap Study (TIPS)-3 randomized controlled trial | P Joseph, *P Pais*, P Gao, K Teo, *D Xavier*, P Lopez-Jaramillo, K Yusoff, A Santoso, H Gamra, SH Talukder, C Christou, G Dagenais, J Tyrwhitt, J Bosch, A Dans, S Yusuf, International Polycap Study Investigators. | Nutrition, Metabolism and Cardiovascular Diseases (NMCD) | 2022 |
| 46 | The Anti-Coronavirus Therapy (ACT) trials: design, baseline characteristics, and challenges | Eikelboom J, Rangarajan S, Jolly SS, Belley-Cote EP, *Prem Pais*, *Xavier D*, Whitlock R, Beresh H, Lewis G, Xu L, Chan N, Bangdiwala S, Diaz R, et all | CJC open | 2022 |
| 47 | Anger or emotional upset and heavy physical exertion as triggers of stroke: the INTERSTROKE study | Smyth A, O’Donnell M, Hankey GJ, Rangarajan S, Lopez-Jaramillo P, *Xavier D*, Zhang H, Canavan M, Damasceno A, Langhorne P, Avezum A, INTERSTROKE investigators | European Heart Journal | 2022 |
| 48 | HbA1c Reduction in Dulaglutide-Treated Patients Irrespective of Duration of Diabetes, Microvascular Disease, and BMI: A Post Hoc Analysis From the REWIND Trial | Anita YM Kwan, Hertzel C Gerstein, Jan Basile, *Denis Xavier*, Juan M Maldonado, Sohini Raha, Manige Konig | Diabetes Care | 2022 |
| 49 | Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial. | Amit X Garg, Meaghan Cuerden, Richard Whitlock, Maria Wittmann, *Denis Xavier*, PJ Devereaux, Hector Aguado, Mohammed Amir, Emilie P Belley-Cote, Keyur Bhatt, Bruce M Biccard Michael McGillion, William McIntyre, Christian Meyhoff, Sandra Ofori, Thomas Painter, Pilar Paniagua, Chirag Parikh, Joel Parlow, Ameen Patel, Carisi Polanczyk, Toby Richards, Pavel Roshanov, et al. | Canadian Journal of Kidney Health and Disease. | 2022 |
| 50 | The Cost Implications of a Polypill for Primary Prevention in the TIPS-3 Trial | Andre Lamy, Wesley Tong, Philip Joseph, Prem Pais, Patricio Lopez-Jaramillo, Tony Dans, Denis Xavier, Shamim Talukder, Anwar Santoso, Habib Gamra, Salim Yusuf, | European Heart Journal | 2022 |
| 51 | Anger or emotional upset and heavy physical exertion as triggers of stroke: the INTERSTROKE study | Andrew Smyth, Martin O’Donnell, Graeme J Hankey, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Denis Xavier, Salim Yusuf | European Heart Journal | 2022 |
| 52 | Health and economic impact of air pollution in the states of India: the Global Burden of Disease Study 2019 | Anamika Pandey, Michael Brauer, Maureen L Cropper, Kalpana Balakrishnan, Prashant Mathur, *Denis Xavier*, Sagnik Dey, Burak Turkgulu, G Anil Kumar, Mukesh Khare, Gufran Beig, Tarun Gupta, Rinu P Krishnankutty, Kate Causey, Aaron J Cohen, Stuti Bhargava, Ashutosh N Aggarwal, Anurag Agrawal, Shally Awasthi, Fiona Bennitt. et al. | The Lancet Planetary Health. | 2021 |
| 53 | Antihypertensives and Statin Therapy for Primary Stroke Prevention | Bosch J, Lonn EM, Dagenais GR, Gao P, Jaramillo PL, Zhu J, *Pais P*, Yusuf S ,for the HOPE-3 Investigators | ahajournals | 2021 |
| 54 | Erectile function in men with type 2 diabetes treated with dulaglutide: an exploratory analysis of the REWIND placebo-controlled randomised trial | Harpreet S Bajaj, Hertzel C Gerstein, Purnima Rao-Melacini, Jan Basile, Helen Colhoun, Ignacio Conget, William C Cushman, *Denis Xavier*, Gilles R Dagenais, Edward Franek, Markolf Hanefeld, Matyas Keltai, Mark Lakshmanan, Fernando Lanas, Lawrence A Leiter, Patricio Lopez-Jaramillo, Valdis Pirags, Nana Pogosova , Jeffrey Probstfield, Peter Raubenheimer, Lars Ryden, Jonathan E Shaw, Wayne H-H Sheu | Lancet Diabetes Endocrinol | 2021 |
| 55 | A qualitative, grounded theory exploration of the determinants of self-care behavior among Indian patients with a lived experience of chronic heart failure | Deepak Y Kamath , K B Bhuvana , Luke Joshua Salazar , Kiron Varghese , Anant Kamath , Jyoti Idiculla 6, Prem Pais , Shruthi Kulkarni , Bradi B Granger , Denis Xavier | PLoS One | 2021 |
| 56 | Efficacy and Safety of Dulaglutide in Older Patients: A post hoc Analysis of the REWIND trial | Matthew C Riddle, Hertzel C Gerstein, Denis Xavier, William C Cushman, Lawrence A Leiter, et al | The Journal of Clinical Endocrinology and Metabolism | 2021 |
| 57 | Hydroxychloroquine for SARS CoV2 Prophylaxis in Healthcare Workers – A Multi-centric Cohort Study Assessing Effectiveness and Safety | Badyal Dinesh, Chandy Sujith J, Chugh Preeta Kaur, Faruqui Atiya, Gupta Yk, Hazra Avijit, Kamat Sandhya, Kamboj Vp, Kaul Rajani, Kshirsagar Nilima, Maulik Subir, Medhi Bikash, Menon Geetha, Ranjalkar Jaya, Rao Vishnu, Shetty Yashashri, Tripathi Raakhi, *Xavier Denis* | J Association Phys India | 2021 |
| 58 | Prevalence of modifiable cardiovascular risk factors among coffee estate workers in rural South India (CARE) | Sitarah Mathias, Akhil Xavier Joseph, Tanvi Jadhav, *Denis Xavier* | Indian Journal of Community Medicine | 2021 |
| 59 | Prevalence of modifiable cardiovascular risk factors among coffee estate workers in rural South India (CARE) | Sitarah Mathias, Akhil Xavier Joseph, Tanvi Jadhav, Denis Xavier | Indian Journal of Community Medicine | 2021 |
| 60 | Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study | Andrew Smyth, Conor Judge, Xingu Wang, Guillaume Pare, *Denis Xavier*, Sumathy Rangarajan, Michelle Canavan, Siu Lim Chin, Fawaz Al-Hussain, Afzalhussein M Yusufali, Ahmed Elsayed, Albertino Damasceno, Alvaro Avezum, Anna Czlonkowska, Annika Rosengren, Antonio L Dans, Aytekin Oguz, Charles Mondo, Christian Weimar, Danuta Ryglewicz, Fernando Lanas, German Malaga, Graeme J Hankey, Helle K Iversen, Hongye Zhang, Khalid Yusoff, Nana Pogosova, Patricio Lopez-Jamarillo, Peter Langhorne, Rafael Diaz, Shahram Oveisgharan, Salim Yusuf, Martin O'Donnell, INTERSTROKE investigators | Neuro epidemiology | 2021 |
| 61 | Safety of hydroxychloroquine in healthcare workers for COVID-19 prophylaxis | Atiya R Faruqui, *Denis Xavier*, Sandhya K Kamat, Sujith J Chandy, Bikash Medhi, Raakhi K Tripathi, Yashashri C Shetty | The Indian Journal of Medical Research | 2021 |
| 62 | The role and challenges of cluster randomised trials for global health | Louis Dron, Monica Taljaard, Yin Bun Cheung, Rebecca Grais, Nathan Ford, Denis Xavier, et al | The Lancet Global Health | 2021 |
| 63 | Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3study | Jackie Bosch, Eva M Lonn, Hyejung Jung, Jun Zhu, Lisheng Liu, Patricio Lopez-Jaramillo, *Prem Pais*, *Denis Xavier*, Rafael Diaz, Gilles Dagenais, Antonio Dans, Alvaro Avezum, Leopoldo S Piegas, Alexander Parkhomenko, Kati Keltai, Matyas Keltai, Karen Sliwa, Claus Held, Ronald J G Peters, Basil S Lewis, Petr Jansky, Khalid Yusoff, Kamlesh Khunti, William D T, Christopher M Reid, John Varigos, Philip Joseph, Lawrence A Leiter, Salim Yusuf | European Heart Journal | 2021 |
| 64 | Three week compared to seven week run-in period length and the assessment of pre-randomization adherence: A study within a trial | David Collister, Lawrence Mbuagbaw, Gordon Guyatt, PJ Devereaux, Karthik K, Tennankore, Gilmar Reis, Laura Sola, *Denis Xavier*, Vivekanand Jha, Martin Gallagher, Antonio L Dans, Wen Liu, Janak de Zoysa, Camilo Félix, Patrick B Mark, Zuo Li, Jessica Tyrwhitt, Joanne Wilkinson, Patrick Sheridan, Fei Yuan, Michael Walsh, ACHIEVE investigators | Contemporary Clinical Trials, 2021 | 2021 |
| 65 | The Cost Implications of Dabigatran in Patients with Myocardial Injury After Non-Cardiac Surgery | Andre Lamy, Wesley Tong, Rajibul Mian, Jessica Vincent, Denis Xavier, PJ Devereaux et al | American Journal of Cardiovascular Drugs | 2021 |
| 66 | The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019 | Gagandeep Singh, Meenakshi Sharma, Avina Vongpradith, Han Y Wunrow, Denis Xavier, DK Shukla, K Srinath Reddy, Samiran Panda, Rakhi Dandona, Christopher JL Murray, Theo Vos, RS Dhaliwal, Lalit Dandona | The Lancet Global Health | 2021 |
| 67 | Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis | Philip Joseph, Gholamreza Roshandel, Peggy Gao, *Prem Pais*, Eva Lonn, *Denis Xavier*, Alvaro Avezum, Jun Zhu, Lisheng Liu, Karen Sliwa, Habib Gamra, Shrikant I Bangdiwala, Koon Teo, Jackie Bosch, Gilles R Dagenais, Reza Malekzadeh, Salim Yusuf, Polypill Trialists’ Collaboration | Lancet | 2021 |
| 68 | Topical Controlled Warm Oxygen Therapy Delivered Through a Novel Device (KADAM™) to Treat Diabetic Foot Ulcers: A Randomized Controlled, Open, Pilot Trial | Anirudh V, *Kamath DY*, Ghosh S, *Bhuvana KB*, Sharma S, Maruthy K, *Pais P*, *Xavier D* | Indian Journal of Surgery | 2021 |
| 69 | The Cost Implications of a Polypill for Primary Prevention in the TIPS-3 Trial | Andre Lamy, Wesley Tong, Philip Joseph, Peggy Gao, *Prem Pais*, Patricio Lopez-Jaramillo, Marjan Walli-Attaei, Tony Dans, *Denis Xavier*, Shamim Talukder, Anwar Santoso, Habib Gamra, Salim Yusuf, TIPS-3 Investigators | European Society of Cardiology | 2021 |
| 70 | Erectile function in men with type 2 diabetes treated with dulaglutide: an exploratory analysis of the REWIND placebo-controlled randomised trial | Harpreet S Bajaj, Hertzel C Gerstein, Purnima Rao-Melacini, Jan Basile, Helen Colhoun, Ignacio Conget, William C Cushman, *Denis Xavier*, Gilles R Dagenais, Edward Franek, Markolf Hanefeld, Matyas Keltai, Mark Lakshmanan, Fernando Lanas, Lawrence A Leiter, Patricio Lopez-Jaramillo, Valdis Pirags, Nana Pogosova , Jeffrey Probstfield, Peter Raubenheimer, Lars Ryden, Jonathan E Shaw, Wayne H-H Sheu | The Lancet Diabetes & Endocrinology | 2021 |
| 71 | Antihypertensives and Statin Therapy for Primary Stroke Prevention | Bosch J, Lonn EM, Dagenais GR, Gao P, Jaramillo PL, Zhu J, *Pais P*, Yusuf S ,for the HOPE-3 Investigators | Stroke | 2021 |
| 72 | Premature permanent discontinuation of apixaban or warfarin in patients with atrial fibrillation | Anthony P Carnicelli, Sana M Al-Khatib, Denis Xavier, Frederik Dalgaard, Peter D Merrill, Daniel M Wojdyla, Basil S Lewis, Michael Hanna, John H Alexander, Renato D Lopes, Lars Wallentin, Christopher B Granger | Heart | 2021 |
| 73 | Regional variation in clinical characteristics and outcomes in patients with atrial fibrillation: Findings from the ARISTOTLE trial | Bahit MC, Granger CB, Alexander JH, Mulder H, Wojdyla DM, Hanna M, Goto S, Xavier D, Verheugt FWA, Lanas F, Hijazi Z, Wallentin L, Lopes RD | Int J Cardiol | 2020 |
| 74 | One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery | Sessler DI, Conen D, Leslie K, Yusuf S, Popova E, Graham M, Kurz A, Villar JC, Mrkobrada M, Sigamani A, Biccard BM, Meyhoff CS, Parlow JL, Guyatt G, Xavier D, Chan MTV, Kumar PA, Forget P, Malaga G, Fleischmann E, Amir M, Torres D, Wang CY, Paniagua P, Berwanger O, Srinathan S, Landoni G, Manach YL, Whitlock R, Lamy A, Balasubramanian K, Gilron I, Turan A, Pettit S, Devereaux PJ; Perioperative Ischemic Evaluation-2 Trial (POISE-2) Investigators. | Anesthesiology | 2020 |
| 75 | Patient and caregiver reported facilitators of self-care among patients with chronic heart failure: report from a formative qualitative study | Kamath DY, Bhuvana KB, Dhiraj RS, Xavier D, Varghese K, Salazar LJ, Granger CB, Pais P, Granger BB | Wellcome Open Res | 2020 |
| 76 | Nocturnal hypertension and left ventricular hypertrophy in pediatric renal transplant recipients in South India | Pais P, Dello Strologo L, Iyengar A, Velusamy V, Greenbaum LA | Pediatr Transplant | 2020 |
| 77 | In Patients With Stable Coronary Heart Disease, Low-Density Lipoprotein-Cholesterol Levels < 70 mg/dL and Glycosylated Hemoglobin A1c < 7% Are Associated With Lower Major Cardiovascular Events | White HD, Stewart RAH, Dalby AJ, Stebbins A, Cannon CP, Budaj A, Linhart A, Pais P, Diaz R, Steg PG, Krug-Gourley S, Granger CB, Hochman JS, Koenig W, Harrington RA, Held C, Wallentin L, STABILITY Investigators | Am Heart J | 2020 |
| 78 | Resource and Infrastructure-Appropriate Management of ST-Segment Elevation Myocardial Infarction in Low- And Middle-Income Countries | Chandrashekhar Y, Alexander T, Mullasari A, Kumbhani DJ, Alam S, Alexanderson E, Bachani D, Badenhorst JCW, Baliga R, Bax JJ, Bhatt DL, Bossone E, Botelho R, Chakraborthy RN, Chazal RA, Dhaliwal RS, Gamra H, Harikrishnan SP, Jeilan M, Kettles DI, Mehta S, Mohanan PP, Naber CK, Naik N, Ntsekhe M, Otieno HA, Pais P, Piñeiro DJ, Prabhakaran D, Reddy KS, Redha M, Roy A, Sharma M, Shor R, Snyders FA, Tan JWC, Valentine CM, Wilson BH, Yusuf S, Narula J | Circulation | 2020 |
| 79 | Effect of Dulaglutide on Cognitive Impairment in Type 2 Diabetes: An Exploratory Analysis of the REWIND Trial | Cukierman-Yaffe T, Gerstein HC, Colhoun HM, Diaz R, García-Pérez LE, Lakshmanan M, Bethel A, Xavier D, Probstfield J, Riddle MC, Rydén L, Atisso CM, Hall S, Rao-Melacini P, Basile J, Cushman WC, Franek E, Keltai M, Lanas F, Leiter LA, Lopez-Jaramillo P, Pirags V, Pogosova N, Raubenheimer PJ, Shaw JE, Sheu WH, Temelkova-Kurktschiev T | Lancet Neurol | 2020 |
| 80 | Dulaglutide reduces HbA1c irrespective of antihyperglycemic agents, duration of diabetes, BMI and weight loss: A post hoc analysis from the REWIND Trial | Kwan A, Gerstein H, Xavier D, Basile J, Maldonado J, Raha S, Konig M | J Am Coll Cardiol | 2020 |
| 81 | Assessment of Dulaglutide Safety in Older Patient Populations in REWIND | Konig M, Gerstein HC, Lakshmanan MC, Xavier D, Allen S, Cushman WC, Leiter LA, Raubenheimer PJ | Journal of the Endocrine Society | 2020 |
| 82 | Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin | Ferrannini G, Gerstein H, Colhoun HM, Dagenais GR, Diaz R, Dyal L, Lakshmanan M, Mellbin L, Probstfield J, Riddle MC, Shaw JE, *Pais P*, et al.. | Eur Heart J | 2020 |
| 83 | Urinary Sodium and Potassium, and Risk of Ischaemic and Haemorrhagic Stroke (INTERSTROKE): a case-control study | Judge C, O'Donnell MJ, Hankey GJ, Rangarajan S, Chin SL, Rao-Melacini P, Ferguson J, Smyth A, Xavier D, Lisheng L, Zhang H, Lopez-Jaramillo P, Damasceno A, Langhorne P, Rosengren A, Dans AL, Elsayed A, Avezum A, Mondo C, Ryglewicz D, Czlonkowska A, Pogosova N, Weimar C, Diaz R, Yusoff K, Yusufali A, Oguz A, Wang X, Lanas F, Ogah OS, Ogunniyi A, Iversen HK, Malaga G, Rumboldt Z, Oveisgharan S, Hussain FA, Yusuf S | Am J Hypertens | 2020 |
| 84 | Polypill with or without Aspirin in Persons without Cardiovascular Disease | Yusuf S, Joseph P, Dans A, Gao P, Teo K, Xavier D, López-Jaramillo P, Yusoff K, Santoso A, Gamra H, Talukder S, Christou C, Girish P, Yeates K, Xavier F, Dagenais G, Rocha C, McCready T, Tyrwhitt J, Bosch J, Pais P; International Polycap Study 3 Investigators | N Engl J Med | 2020 |
| 85 | Situational analysis of practice patterns and challenges in cardiovascular disease management: A qualitative study | Farah Naaz Fathima, Twinkle Agrawal, Padmini Nidhin, *Denis Xavier* | Int. J of Non communicable Diseases | 2020 |
| 86 | Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial | Washam JB, Hohnloser SH, Lopes RD, Wojdyla DM, Vinereanu D, Alexander JH, Gersh BJ, Hanna M, Horowitz J, Hylek EM, Xavier D, Verheugt FWA, Wallentin L, Granger CB; ARISTOTLE Committees and Investigators. | J Thromb Thrombolysis | 2019 |
| 87 | Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial | Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, Probstfield J, Riesmeyer JS, Riddle MC, Rydén L, Xavier D, Atisso CM, Dyal L, Hall S, Rao-Melacini P, Wong G, Avezum A, Basile J, Chung N, Conget I, Cushman WC, Franek E, Hancu N, Hanefeld M, Holt S, Jansky P, Keltai M, Lanas F, Leiter LA, Lopez-Jaramillo P, Cardona Munoz EG, Pirags V, Pogosova N, Raubenheimer PJ, Shaw JE, Sheu WH, Temelkova-Kurktschiev T; REWIND Investigators. | Lancet | 2019 |
| 88 | Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial | Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, Probstfield J, Botros FT, Riddle MC, Rydén L, Xavier D, Atisso CM, Dyal L, Hall S, Rao-Melacini P, Wong G, Avezum A, Basile J, Chung N, Conget I, Cushman WC, Franek E, Hancu N, Hanefeld M, Holt S, Jansky P, Keltai M, Lanas F, Leiter LA, Lopez-Jaramillo P, Cardona Munoz EG, Pirags V, Pogosova N, Raubenheimer PJ, Shaw JE, Sheu WH, Temelkova-Kurktschiev T; REWIND Investigators | Lancet | 2019 |
| 89 | Association between complications and death within 30 days after noncardiac surgery | Spence J, LeManach Y, Chan MTV, Wang CY, Sigamani A, Xavier D, Pearse R, Alonso-Coello P, Garutti I, Srinathan SK, Duceppe E, Walsh M, Borges FK, Malaga G, Abraham V, Faruqui A, Berwanger O, Biccard BM, Villar JC, Sessler DI, Kurz A, Chow CK, Polanczyk CA, Szczeklik W, Ackland G, Garg AX, Jacka M, Guyatt GH, Sapsford RJ, Williams C, Cortes OL, Coriat P, Patel A, Tiboni M, Belley-Côté EP, Yang S, Heels-Ansdell D, McGillion M, Schünemann HJ, Parlow S, Patel M, Pettit S, Yusuf S, Devereaux PJ; on behalf of the VISION Investigators | CMAJ | 2019 |
| 90 | Cardiovascular risk factor reduction by community health workers in rural India: A cluster randomized trial | Joshi R, Agrawal T, Fathima F, Usha T, Thomas T, Misquith D, Kalantri S, Chidambaram N, Raj T, Singamani A, Hegde S, Xavier D, Devereaux PJ, Pais P, Gupta R, Yusuf S | Am Heart J | 2019 |
| 91 | Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome treated medically or with percutaneous coronary intervention or undergoing elective percutaneous coronary intervention: insights from the AUGUSTUS trial | Stephan Windecker, Renato D Lopes, Tyler Massaro, Charlotte Jones-Burton, Christopher B Granger, Robert C Welsh, Denis Xavier, Roxana Mehran, John H Alexander et al | Circulation | 2019 |
| 92 | Alirocumab reduces total hospitalizations and increases days alive and out of hospital in the ODYSSEY OUTCOMES trial | 142. Michael Szarek, Ph Gabriel Steg, Dina DiCenso, Deepak L Bhatt, Vera A Bittner, Andrzej Budaj, Rafael Diaz, Shaun G Goodman, Nina Gotcheva, J Wouter Jukema, Robert Pordy, Matthew T Roe, Timothée Sourdille, Harvey D White, Denis Xavier, et al. | Circulation: Cardiovascular Quality and Outcomes | 2019 |
| 93 | Prescription Pattern, Short-Term Outcomes, and Its Determinants in Patients With Chronic Kidney Disease Attending a Tertiary Care Hospital | Mamadi RK, Sathish R, Selvaraj DR, Rathore R, Jose JV, Xavier D | Indian J Pharmacol | 2019 |
| 94 | The impact of air pollution on deaths, disease burden, and life expectancy across the states of India: the Global Burden of Disease Study 2017. | K Balakrishnan, S Dey, T Gupta, RS Dhaliwal, M Brauer, AJ Cohen, *D Xavier*, et al.. | The Lancet Planetary Health. | 2019 |
| 95 | Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial | Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, *Pais P*, *Xavier D*, Atisso CM, et al.. | The Lancet | 2019 |
| 96 | Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial. | Ray, Kausik K; Colhoun, Helen M; Szarek, Michael; Baccara-Dinet, Marie; Bhatt, Deepak L; Bittner, Vera A; Budaj, Andrzej J; Diaz, Rafael; Goodman, Shaun G; Hanotin, Corinne; Denis Xavier et al | The Lancet Diabetes and Endocrinology | 2019 |
| 97 | Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial | Devereaux PJ, Duceppe E, Guyatt G, Tandon V, Rodseth R, Biccard BM, Xavier D, Szczeklik W, Meyhoff CS, et al; MANAGE Investigators | Lancet | 2018 |
| 98 | Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016 | Fullman N, Yearwood J, Abay SM, Abbafati C, Abd-Allah F, Abdela J, Xavier D, et al; GBD 2016 Healthcare Access and Quality Collaborators | Lancet | 2018 |
| 99 | First Stroke Reduced 44 Percent by Well Tolerated Medications. Stroke Outcomes From the Heart Outcomes Prevention Evaluation 3 Study | Bosch J, Lonn E, Zhu J, Pais P, Xavier D, Dans A, Diaz R, Hart R, Yusuf S | Stroke | 2018 |
| 100 | The International Polycap Study-3 (TIPS-3): Design, baseline characteristics and challenges in conduct | P Joseph, P Pais, AL Dans, J Bosch, D Xavier, P Lopez-Jaramillo, et al | American Heart Journal | 2018 |
| 101 | Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events in the ODYSSEY OUTCOMES Trial | Szarek M, White HD, Schwartz GG, Alings M, Bhatt DL, Bittner VA, Chiang CE, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Kimura T, Kiss RG, Lecorps G, Mahaffey KW, Moryusef A, Pordy R, Roe MT, Tricoci P, Xavier D, Zeiher AM, Steg PG; ODYSSEY OUTCOMES Committees and Investigators. | J Am Coll Cardiol | 2018 |
| 102 | Treadmill stress tests should not be part of "routine health check package" | Pais P | Indian Heart Journal | 2018 |
| 103 | Low quality cardiovascular care is important coronary risk factor in India | Gupta R, Khedar RS, Gaur K, Xavier D | Indian Heart Journal | 2018 |
| 104 | Effect of intensive lifestyle modification & metformin on cardiovascular risk in prediabetes: A pilot randomized control trial | Kulkarni S, Xavier D, George B, Umesh S, Fathima S, Bantwal G | Indian J Med Res | 2018 |
| 105 | The changing patterns of cardiovascular diseases and their risk factors in the states of India: the Global Burden of Disease Study 1990-2016 | Prabhakaran D, Jeemon P, Sharma M, Roth GA, Johnson C, Harikrishnan S, Gupta R, Pandian JD, Naik N, Roy A, Dhaliwal RS, Xavier D, et al; India State-Level Disease Burden Initiative CVD Collaborators | Lancet Glob Health | 2018 |
| 106 | Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017 | Roth GA, Abate D, Abate KH, Abay SM, Xavier D, et.al; GBD 2017 Causes of Death Collaborators | Lancet | 2018 |
| 107 | Community Health Worker Interventions in Type 2 Diabetes Mellitus Patients: Assessing the Feasibility and Effectiveness in Rural Central India | Jain V, Joshi R, Idiculla J, Xavier D | Journal of Cardiovascular Disease Research | 2018 |
| 108 | Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 | Stanaway JD, Afshin A, Gakidou E, Lim SS, Xavier D, et.al; GBD 2017 Risk Factor Collaborators | Lancet | 2018 |
| 109 | The increasing burden of diabetes and variations among the states of India: the Global Burden of Disease Study 1990–2016 | N Tandon, RM Anjana, V Mohan, T Kaur, A Afshin, K Ong, D Xavier et al. | The Lancet Global Health | 2018 |
| 110 | Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 | Spencer L James, Degu Abate, Kalkidan Hassen Abate, *Denis Xavier*, et al .. | Lancet | 2018 |
| 111 | Impact of blood pressure lowering, cholesterol lowering and their combination in Asians and non-Asians in those without cardiovascular disease: an analysis of the HOPE 3 STUDY | *Pais P*, Jung H, Dans A, Zhu J, Liu L, *Kamath D*, Bosch J, Lonn E & Yusuf S, *Denis Xavier*, et al.. | Eur J Prev Cardiol | 2018 |
| 112 | Impact of a multifaceted educational intervention on oral anticoagulation (OAC) use in atrial fibrillation (AF) patients according to aspirin use at baseline: insights from impact-AF trial. | Jie Jiang, Ying Xian, Hussein Al-Khalidi, Maria Bahit, Renato Lopes, Dragos Vinereanu, *Denis Xavier*, He Pengkang, He Wensheng, Andrea Ciobanu, *Deepak Kamanth*, et al.. | Journal of the American College of Cardiology | 2018 |
| 113 | Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health- related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. | Rafael Lozano, Nancy Fullman, Degu Abate, Solomon M Abay, Cristiana Abbafati, *Denis Xavier*, et al.. | The Lancet | 2018 |
| 114 | Practice patterns and outcomes after stroke across countries at different economic levels (INTERSTROKE): an international observational study | P Langhorne, MJ O'Donnell, SL Chin, H Zhang, D Xavier, A Avezum, et al. | The Lancet | 2018 |
| 115 | Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery | Graham MM, Sessler DI, Parlow JL, Biccard BM, Guyatt G, Xavier D, et al. | Annals of Internal Medicine | 2018 |
| 116 | Improving Evidence for Implementation of Guideline-Based Care in Low- and Middle-Income Countries | Granger CB, Xavier D | JAMA | 2018 |
| 117 | Design and baseline characteristics of participants in the Researching Cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide | Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, Probstfield J, Riddle MC, Rydén L, Xavier D et al | Diabetes, Obesity and Metabolism | 2018 |
| 118 | Design of a Randomized Placebo-Controlled Trial to Assess Dabigatran and Omeprazole in Patients with Myocardial Injury after Noncardiac Surgery (MANAGE) | Duceppe E, Yusuf S, Tandon V, Rodseth R, Biccard BM, Xavier D, Szczeklik W, Meyhoff CS, Franzosi MG, Vincent J, Srinathan SK, Parlow J, Magloire P, Neary J, Rao M, Chaudhry NK, Mayosi B, de Nadal M, Popova E, Villar JC, Botto F, Berwanger O, Guyatt G, Eikelboom JW, Sessler DI, Kearon C, Pettit S, Connolly SJ, Sharma M, Bangdiwala SI, Devereaux PJ | Can J Cardiol | 2018 |
| 119 | Anti-Inflammatory Therapy with Canakinumab for the Prevention and Management of Diabetes | Everett BM, Donath MY, Pradhan AD, Thuren T, Pais P, Nicolau JC, Glynn RJ, Libby P, Ridker PM | J Am Coll Cardiol | 2018 |
| 120 | Divergent trends in ischaemic heart disease and stroke mortality in India from 2000 to 2015: a nationally representative mortality study | Ke C, Gupta R, Xavier D, Prabhakaran D, Mathur P, Kalkonde YV, Kolpak P, Suraweera W, Jha P; Million Death Study Collaborators. | Lancet Glob Health | 2018 |
| 121 | Low quality cardiovascular care is important coronary risk factor in India | Gupta R, Khedar RS, Gaur K, Xavier D | Indian Heart Journal | 2018 |
| 122 | Hypertension: The most important non communicable disease risk factor in India | Gupta R, Xavier D | Indian Heart Journal | 2018 |
| 123 | Nations within a nation: variations in epidemiological transition across the states of India, 1990-2016 in the Global Burden of Disease Study | Kurpad A, Xavier, D, et al; India State-Level Disease Burden Initiative Collaborators | Lancet | 2017 |
| 124 | Home Blood Pressure Management Intervention in Low- to Middle-Income Countries: Protocol for a Mixed Methods Study | Anderson C, Dadabhai S, Damasceno A, Dzudie A, Islam SMS, Kamath D, Kandula N, Kayange N, Quispe R, Roy A, Shah S, Vidal-Perez R | JMIR Res Protoc | 2017 |
| 125 | Regional differences in presentation and antithrombotic treatment of patients with atrial fibrillation: Baseline characteristics from a clustered randomized trial to IMProve treatment with AntiCoagulanTs in patients with atrial fibrillation (IMPACT-AF) | Vinereanu D, Al-Khalidi HR, Rao MP, He W, Lopes RD, Xavier D, et al | American Heart Journal | 2017 |
| 126 | Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease | Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ; CANTOS Trial Group. | N Engl J Med | 2017 |
| 127 | A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial | Dragos Vinereanu , Renato D Lopes , M Cecilia Bahit , Denis Xavier , Jie Jiang , Hussein R Al-Khalidi , Wensheng He , Ying Xian , Andrea O Ciobanu , Deepak Y Kamath , Kathleen A Fox , Meena P Rao , Sean D Pokorney , Otavio Berwanger , Carlos Tajer , Pedro G M de Barros E Silva , Mayme L Roettig , Yong Huo , Christopher B Granger IMPACT-AF investigators | Lancet | 2017 |
| 128 | Association of postoperative high-sensitivity troponin levels with myocardial injury and 30-day mortality among patients undergoing noncardiac surgery | Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, et al. | Journal of the American Medical Association | 2017 |
| 129 | The World Heart Federation Roadmap for Nonvalvular Atrial Fibrillation | Murphy A, Banerjee A, Breithardt G, Camm AJ, Commerford P, Xavier D, et al. | Global Heart Journal | 2017 |
| 130 | Primary Healthcare-based Diabetes Registry in Puducherry: Design and Methods | Lakshminarayanan S, Kar SS, Gupta R, Xavier D, Bhaskar Reddy SV | Indian Journal of Endocrinology and Metabolism | 2017 |
| 131 | Predictors, Prognosis, and Management of New Clinically Important Atrial Fibrillation After Noncardiac Surgery: A Prospective Cohort Study | Alonso-Coello P, Cook D, Xu SC, Sigamani A, Berwanger O, Sivakumaran S, Yang H, Xavier D, Martinez LX, Ibarra P, Rao-Melacini P, Pogue J, Zarnke K, Paniagua P, Ostrander J, Yusuf S, Devereaux PJ; POISE Investigators | Anesth Analg | 2017 |
| 132 | Uses of polypills for cardiovascular disease and evidence to date | Huffman MD, Xavier D, Perel P | Lancet | 2017 |
| 133 | Use of interacting drugs did not modify treatment effects of apixaban versus warfarin for atrial fibrillation: results from the Aristotle trial | 111. Jeffrey B. Washam, Stefan Hohnloser, Daniel Wojdyla, Dragos Vinereanu, John Alexander, Denis Xavier, et al | JACC | 2017 |
| 134 | Primary Healthcare-based Diabetes Registry in Puducherry: Design and Methods | Lakshminarayanan S, Kar SS, Gupta R, Xavier D, Bhaskar Reddy SV | Indian Journal of Endocrinology and Metabolism | 2017 |
| 135 | Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease | Yusuf S, Bosch J.,Dagenais G, Zhu J, *Xavier D*, Liu L, *Pais P*, López-Jaramillo P, Leiter LA, et al., | The New England Journal of Medicine | 2016 |
| 136 | Global, regional, and national Incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015 | Vos T, Allen C, Arora M, Cornaby L, Dandona L, *Xavier D*, et al.. | Lancet | 2016 |
| 137 | Non-physician health workers for improving adherence to medications and healthy lifestyle following acute coronary syndrome: 24-month follow-up study | KK Sharma, R Gupta, *M Mathur*, V Natani, S Lodha, S Roy, *D Xavier*. | Indian Heart Journal | 2016 |
| 138 | Treatments and outcomes of cardiac arrhythmias after myocardial infarction: a prospective, follow up study in a tertiary-care hospital. | A Pandit, K Verghese, R Rathore, *D Xavier*. | International Education and Research Journal | 2016 |
| 139 | Cardiovascular risk factors and determinants of clinical outcomes in type 2 diabetic patients at a tertiary-care centre | Maria Jose, Aparna Manjunath, Ganapathy Bantwal, *Denis Xavier* | International Journal Basic Clin Pharmacol | 2016 |
| 140 | Prevalence of Pragmatically Defined High CV Risk and its Correlates in LMIC: A Report From 10 LMIC Areas in Africa, Asia, and South America | 92. Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Xian Li, Chendi Cui, Xiaolin Xu, Denis Xavier et al. | The Journal of Global heart. | 2016 |
| 141 | Community health worker-based intervention for adherence to drugs and lifestyle change after acute coronary syndrome: a multicentre, open, randomised controlled trial | Xavier D, Gupta R, Kamath D, Sigamani A, Devereaux PJ, George N, Joshi R, Pogue J, Pais P, Yusuf S | Lancet Diabetes Endocrinol | 2016 |
| 142 | Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. | O'Donnell MJ, Chin SL, Rangarajan S, Xavier D, Liu L, Zhang H, Rao-Melacini P, Zhang X, Pais P, et al. | Lancet | 2016 |
| 143 | Hypertension Prevalence, Awareness, Treatment, and Control in Selected LMIC Communities: Results From the NHLBI/UHG Network of Centers of Excellence for Chronic Diseases | Irazola VE, Gutierrez L, Bloomfield G, Carrillo-Larco RM, Dorairaj P, Gaziano T, Levitt NS, Miranda JJ, Ortiz AB, Steyn K, Wu Y, Xavier D, Yan LL, He J, Rubinstein A | Glob Heart | 2016 |
| 144 | Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease | 95. Lonn E M, Bosch J, López-Jaramillo P, Zhu J, Liu L Pais P, Diaz R, Xavier D, Sliwa K, Dans, A et al. | The New England Journal of Medicine | 2016 |
| 145 | Training and Capacity Building in LMIC for Research in Heart and Lung Diseases: The NHLBI-UnitedHealth Global Health Centers of Excellence Program | Bloomfield GS, Xavier D, Belis D, Alam D, Davis P, Dorairaj P, Ghannem H, Gilman RH, Kamath D, et al. | Glob Heart | 2016 |
| 146 | A clustered randomized trial to IMProve treatment with AntiCoagulanTs in patients with Atrial Fibrillation (IMPACT-AF): design and rationale | Meena P Rao, Andrea O Ciobanu, Renato D Lopes, Kathleen A Fox, Ying Xian, Denis Xavier, et al. | American Heart Journal | 2016 |
| 147 | Comparison of Nonblood-Based and Blood-Based Total CV Risk Scores in Global Populations | Gaziano TA, Abrahams-Gessel S, Alam S, Alam D, Ali M, Bloomfield G, Carrillo-Larco RM, Dorairaj P, Gutierrez L, Irazola V, Levitt NS, Miranda JJ, Bernabe-Ortiz A, Pandya A, Rubinstein A, Steyn K, Xavier D, Yan LL | Glob Heart | 2016 |
| 148 | Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation: post hoc analysis of the ARISTOTLE trial | Jaspers Focks J, Brouwer MA, Wojdyla DM, Thomas L, Lopes RD, Washam JB, Lanas F, Xavier D, Husted S, Wallentin L, Alexander JH, Granger CB, Verheugt FW | BMJ | 2016 |
| 149 | Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease | Salim Yusuf Eva Lonn , Prem Pais , Jackie Bosch , Patricio López-Jaramillo , Jun Zhu , Denis Xavier , Alvaro Avezum , Lawrence A Leiter , Leopoldo S Piegas , Alexander Parkhomenko ,Matyas Keltai , Katalin Keltai,, Karen Sliwa , Irina Chazova , Ron J G Peters , Claes Held , Khalid Yusoff , Basil S Lewis , Petr Jansky , Kamlesh Khunti , William D Toff , Christopher M Reid , John Varigos , Jose L Accini 1, Robert McKelvie , Janice Pogue , Hyejung Jung , Lisheng Liu , Rafael Diaz , Antonio Dans , Gilles Dagenais 1; HOPE-3 Investigators | N Engl J Med . | 2016 |
| 150 | Occurrence of death and stroke in patients in 47 countries 1 year after presenting with atrial fibrillation: a cohort study | Healey JS, Oldgren J, Ezekowitz M, Zhu J, Pais P, Wang J, Commerford P, Jansky P, Avezum A, Sigamani A, Demasceno A, Reilly P, Grinvalds A, Nakamya J, Aje A, Almahmeed W, Moriarty A, Wallentin L, Yusuf S, Connolly SJ | Lancet | 2016 |
| 151 | Prevalence, risk factors and awareness of hypertension in India: a systematic review | P Devi , M Rao, A Sigamani, A Faruqui, M Jose, R Gupta, P Kerkar, R K Jain, R Joshi, N Chidambaram, D S Rao, S Thanikachalam, S S Iyengar, K Verghese, V Mohan, P Pais, D Xavier | J Hum Hypertens . | 2016 |
| 152 | Age-specific and sex-specific adult mortality risk in India in 2014: analysis of 0·27 million nationally surveyed deaths and demographic estimates from 597 districts | 87. Usha Ram, Prabhat Jha, Patrick Gerland, Ryan J Hum, Peter Rodriguez, Denis Xavier, et al. | The Lancet Global Health | 2015 |
| 153 | High sensitivity C-reactive protein (hsCRP) & cardiovascular disease: An Indian perspective | Deepak Y Kamath, Denis Xavier, Alben Sigamani, Prem Pais | The Indian journal of medical research. | 2015 |
| 154 | Clinical events after transitioning from apixaban versus warfarin to warfarin at the end of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial | Granger CB, Lopes RD, Hanna M, Ansell J, Hylek EM, Alexander JH, Thomas L, Wang J, Bahit MC, Verheugt F, Lawrence J, Xavier D, Wallentin L | Am Heart J | 2015 |
| 155 | Prevalence, treatments and outcomes of coronary artery disease in Indians: A systematic review | Mangala Rao 1, Denis Xavier 2, Padmini Devi 1, Alben Sigamani 1, Atiya Faruqui 1, Rajeev Gupta 3, Prafulla Kerkar 4, Rajendra Kumar Jain 5, Rajnish Joshi 6, N Chidambaram 7, Daya Sagar Rao 8, S Thanikachalam 9, S S Iyengar 10, Kiron Verghese 11, V Mohan 12, Prem Pais 13 | Indian Heart Journal | 2015 |
| 156 | Clinical events after transitioning from apixaban versus warfarin to warfarin at the end of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial | Christopher B. Granger, Renato D. Lopes, Michael Hanna, Jack Ansell, Elaine M. Hylek, John H. Alexander, Laine Thomas, Junyuan Wang, M. Cecilia Bahit, Freek Verheug, Jack Lawrence, *Denis Xavier*, Lars Wallentin. | American Heart Journal January | 2015 |
| 157 | Physicians Perception on Complementary and Alternative Medicine (CAM): A Cross Sectional Survey at Tertiary Care Hospital in India | NS Kunnoor, R Rathore, *D Xavier* | Medicinal chemistry | 2015 |
| 158 | Novel Approaches in Primary Cardiovascular Disease Prevention: The HOPE-3 Trial Rationale, Design, and Participants' Baseline Characteristics | Eva Lonn, Jackie Bosch, Janice Pogue, Alvaro Avezum, *Prem Pais*, *Denis Xavier*, Salim Yusuf, et al. | Canadian Journal of Cardiology | 2015 |
| 159 | Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease | Avezum A,Lopes RD, Schulte PJ, Lanas F, Gersh BJ, Hanna M, *Pais P*, Erol C, Diaz R, Bahit MC, Bartunek J, Caterina RD, Goto S, Ruzyllo W, Zhu J, Granger CB & Alexander JH. | Circulation | 2015 |
| 160 | Clinical outcomes and management associated with major bleeding in patients with atrial fibrillation treated with apixaban or warfarin: insights from the ARISTOTLE trial | Claes Held 1, Elaine M Hylek 2, John H Alexander 3, Michael Hanna 4, Renato D Lopes 3, Daniel M Wojdyla 3, Laine Thomas 3, Hussein Al-Khalidi 3, Marco Alings 5, Dennis Xavier 6, Jack Ansell 7, Shinya Goto 8, Witold Ruzyllo 9, Mårten Rosenqvist 10, Freek W A Verheugt 11, Jun Zhu 12, Christopher B Granger 3, Lars Wallentin 13 | European heart journal | 2015 |
| 161 | Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation: insights from the ARISTOTLE trial | Alexander JH, Lopes RD, Thomas L, Alings M, Atar D, Aylward P, Goto S, Hanna M, Huber K, Husted S, Lewis BS, McMurray JJ, Pais P, Pouleur H, Steg PG, Verheugt FW, Wojdyla DM, Granger CB, Wallentin L | Eur Heart J | 2014 |
| 162 | Rationale and design of a randomized controlled trial evaluating community health worker-based interventions for the secondary prevention of acute coronary syndromes in India (SPREAD) | Kamath DY, Xavier D, Gupta R, Devereaux PJ, Sigamani A, Hussain T, Umesh S, Xavier F, Girish P, George N, Thomas T, Chidambaram N, Joshi R, Pais P, Yusuf S | Am Heart J | 2014 |
| 163 | Efficacy and Safety of Apixaban Compared with Warfarin for Stroke Prevention in Patients with Atrial Fibrillation from East Asia: A Subanalysis of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE)Trial | Goto S, Zhu J, Liu L, Oh BH, Wojdyla DM, Aylward P, Bahit MC, Gersh BJ, Hanna M, Horowitz J, Lopes RD, Wallentin L, Xavier D, Alexander JH; ARISTOTLE Investigators | Am Heart J | 2014 |
| 164 | Management of NCD in low- and middle-income countries | William Checkley 1, Hassen Ghannem 2, Vilma Irazola 3, Sylvester Kimaiyo 4, Naomi S Levitt 5, J Jaime Miranda 6, Louis Niessen 7, Dorairaj Prabhakaran 8, Cristina Rabadán-Diehl 9, Manuel Ramirez-Zea 10, Adolfo Rubinstein 3, Alben Sigamani 11, Richard Smith 12, Nikhil Tandon 13, Yangfeng Wu 14, Denis Xavier 11, Lijing L Yan 15; GRAND South Network, UnitedHealth Group/National Heart, Lung, and Blood Institute Centers of Excellence | Global heart. | 2014 |
| 165 | Management and clinical outcomes in patients treated with apixaban versus warfarin undergoing procedures | Garcia D, Alexander JH, Wallentin L, Wojdyla DM, Thomas L, Hanna M, Al-Khatib SM, Dorian P, Ansell J, Commerford P, Flaker G, Lanas F, Vinereanu D, Xavier D, Hylek EM, Held C, Verheugt FW, Granger CB, Lopes RD | Blood | 2014 |
| 166 | Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes | Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, et al | Anesthesiology | 2014 |
| 167 | Combination pharmacotherapy to prevent cardiovascular disease: present status and challenges. | 67. Yusuf S, Attaran A, Bosch J, Joseph P, Lonn E, McCready T, Mente A, Nieuwlaat R, Pais P, Rodgers A, Schwalm JD, Smith R, Teo K, Xavier D. | European Heart Journal | 2014 |
| 168 | Clonidine in patients undergoing noncardiac surgery | Devereaux PJ, Sigamani A, Xavier D, Yusuf S, et al | N Engl J Med | 2014 |
| 169 | Aspirin in patients undergoing noncardiac surgery | Devereaux PJ, Sigamani A, Xavier D, Yusuf S, et al | N Engl J Med | 2014 |
| 170 | Variations in cause and management of atrial fibrillation in a prospective registry of 15,400 emergency department patients in 46 countries: the RE-LY Atrial Fibrillation Registry | Jonas Oldgren , Jeff S Healey, Michael Ezekowitz, Patrick Commerford, Alvaro Avezum, Prem Pais, Jun Zhu, Petr Jansky, Alben Sigamani, Carlos A Morillo, Lisheng Liu, Albertino Damasceno, Alex Grinvalds, Juliet Nakamya, Paul A Reilly, Katalin Keltai, Isabelle C Van Gelder, Afzal Hussein Yusufali, Eiichi Watanabe, Lars Wallentin, Stuart J Connolly, Salim Yusuf; RE-LY Atrial Fibrillation Registry Investigators | Circulation . | 2014 |
| 171 | Rationale and design of the Primary pREvention strategies at the community level to Promote Adherence of treatments to pREvent cardiovascular diseases trial number (CTRI/2012/09/002981) | Fathima FN, Joshi R, Agrawal T, Hegde S, Xavier D, Misquith D, Chidambaram N, Kalantri SP, Chow C, Islam S, Devereaux PJ, Gupta R, Pais P, Yusuf S | Am Heart J | 2013 |
| 172 | Apixaban versus warfarin in patients with atrial fibrillation according to prior warfarin use: results from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial | Garcia DA, Wallentin L, Lopes RD, Thomas L, Alexander JH, Hylek EM, Ansell J, Hanna M, Lanas F, Flaker G, Commerford P, Xavier D, Vinereanu D, Yang H, Granger CB. | Am Heart J | 2013 |
| 173 | New evidence for gender disparities in cardiac interventions: ‘CREATE’-ing some clarity. | Sigamani A, Kamath D, Xavier D, Pais P. | Future Medicine | 2013 |
| 174 | Dabigatran versus warfarin: effects on ischemic and hemorrhagic strokes and bleeding in Asians and non-Asians with atrial fibrillation | Hori M, Connolly SJ, Zhu J, Liu LS, Lau CP, Pais P, Xavier D, Kim SS, Omar R, Dans AL, Tan RS, Chen JH, Tanomsup S, Watanabe M, Koyanagi M, Ezekowitz MD, Reilly PA, Wallentin L, Yusuf S; RE-LY Investigators. | Stroke | 2013 |
| 175 | Effect of B Vitamins and Lowering Homocysteine on Cognitive Impairment in Patients With Previous Stroke or Transient Ischemic Attack: A Prespecified Secondary Analysis of a Randomized, Placebo-Controlled Trial and Meta-Analysis. | Hankey GJ, Ford AH, Yi Q, Eikelboom JW, Lees KR, Chen C, Xavier D, Navarro JC, Ranawaka UK, Uddin W, Ricci S, Gommans J, Schmidt R, Almeida OP, van Bockxmeer FM; on Behalf of the VITATOPS Trial Study Group. | Stroke | 2013 |
| 176 | The Long-Term Multicenter Observational Study of Dabigatran Treatment in Patients With Atrial Fibrillation (RELY-ABLE) Study | Connolly SJ, Wallentin L, Ezekowitz MD, Pais P, Xavier D, Wang SQ, Yusuf S, et al | Circulation | 2013 |
| 177 | P2Y12 inhibitors in acute coronary syndromes: which and when? | Pais P | Natl Med J India | 2013 |
| 178 | The Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators. Efficacy and Safety of Apixaban Compared With Warfarin at Different Levels of Predicted International Normalized Ratio Control for Stroke Prevention in Atrial Fibrillation Clinical Perspective. | Lars Wallentin, Renato D. Lopes, Michael Hanna, Lain Thomas, Anne Hellkamp, Sunil Nepal, *Denis Xavier* et al | Circulation | 2013 |
| 179 | Polypill Is an Important Strategy for the Prevention of Cardiovascular Disease Risk. | Denis Xavier, Alben Sigamani, Deepak Y. Kamath, Prem Pais. | Journal of Clinical and Preventive Cardiology, | 2012 |
| 180 | Comparison of Risk Factor Reduction and Tolerability of a Full-Dose Polypill (With Potassium) Versus Low-Dose Polypill (Polycap) in Individuals at High Risk of Cardiovascular Diseases | Yusuf S, *Pais P*, Sigamani A, *Xavier D*, Afzal R, Gao P, Teo KK | Circ Cardiovasc Qual Outcomes | 2012 |
| 181 | Low-dose aspirin for preventing recurrent venous thromboembolism | Brighton TA, Eikelboom JW, Mann K, Mister R, Gallus A, Ockelford P, Gibbs H, Hague W, Xavier D, Diaz R, Kirby A, Simes J; ASPIRE Investigators | N Engl J Med | 2012 |
| 182 | Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial | Hankey G, Eikelboom JW, Yi Q, Lees KR, Chen C, Xavier D, Navarro JC, Ranawaka UK, Uddin W, Ricci S, Gommans J, Schmidt R; VITAmins TO Prevent Stroke (VITATOPS) Trial Study Group | Stroke | 2012 |
| 183 | Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. | Devereaux PJ, Chan MT, Sigamani A, Yusuf S, et al; | JAMA | 2012 |
| 184 | Piloting a novel algorithm for glucose control in the coronary care unit: the RECREATE (REsearching Coronary REduction by Appropriately Targeting Euglycemia) trial | Nerenberg KA, Goyal A, Xavier D, Sigamani A, Ng J, Mehta SR, Díaz R, Kosiborod M, Yusuf S, Gerstein HC; RECREATE Investigators | Diabetes Care | 2012 |
| 185 | Effect of fixed dose combinations of metoprolol and amlodipine in essential hypertension: MARS--a randomized controlled trial | Devi P, Xavier D, Sigamani A, Pandey S, Thomas T, Murthy S, Sharma K, Bosco B, Mehta K, Joshi S, Gupta R, Singh G, Hiremath J, Ds C, Nambiar A, Pais P | Blood Press Suppl | 2011 |
| 186 | Characteristics and Short-Term Prognosis of Perioperative Myocardial Infarction in Patients Undergoing Noncardiac Surgery: a cohort study. | Devereaux P.J. Xavier D, Sigamani A, Yusuf S, et al; | Ann Intern Med | 2011 |
| 187 | Translating evidence into policy for cardiovascular disease control in India | Gupta R, Guptha S, Joshi R, Xavier D | Health Res Policy Sys | 2011 |
| 188 | Apixaban versus Warfarin in Patients with Atrial Fibrillation | Granger CB, Alexander JH, Pais P, et al. | N Engl J Med | 2011 |
| 189 | Apixaban with Antiplatelet therapy after acute coronary syndrome. | Alexander JH, Lopes RD, James S, Pais P, et al; | N Engl J Med | 2011 |
| 190 | High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study | Kavsak PA, Walsh M, Sigamani A, Xavier D, Devereaux PJ, et al; | Clin Biochem | 2011 |
| 191 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial | Mehta SR, Tanguay JF, Yusuf S, et al; | Lancet | 2010 |
| 192 | The polypill in the Prevention of Cardiovascular Diseases: Key Concepts, Current Status, Challenges, and Future Directions. | Lonn E, Bosch J, Teo KK, Pais P, Xavier D, Yusuf S. | Circulation | 2010 |
| 193 | Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. | CURRENT-OASIS 7 Investigators, Mehta SR, Bassand JP, Afzal R, Yusuf S, et al; | N Engl J Med | 2010 |
| 194 | Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke. | O'Donnell M, Xavier D, Pias P, Yusuf S et al; | Neuroepidemiology | 2010 |
| 195 | B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo controlled trial. | VITATOPS Trial Study Group, Xavier D, Pais P, et al; | Lancet Neurol. | 2010 |
| 196 | Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. | O'Donnell MJ, Xavier D, Liu L, Yusuf S, Pais P, et al; | Lancet | 2010 |
| 197 | Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial. | FUTURA/OASIS-8 Trial Group, Mehta SR, Afzal R, Xavier D, Pogue J, Yusuf S, et al; | JAMA 2010 | 2010 |
| 198 | Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial. | Diener HC, Connolly SJ, Xavier D, Yusuf S, et al; | Lancet Neurol. | 2010 |
| 199 | Dabigatran versus warfarin in patients with atrial fibrillation. | Connolly SJ, Ezekowitz MD, Yusuf S, Alings M, Xavier D, et al; | N Engl J Med. | 2009 |
| 200 | Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial. | Yusuf S, Pais P, Xavier D, Sigamani A, Mohan V, Gupta R, Thomas N, et al; | Lancet | 2009 |
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Mar 09 - Mar 13, 2026https://bit.ly/SJMCRI_HRM_2026We have been conducting various training programs in Health Research Methods for physicians and researchers…
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We have been conducting various training programs in Health Research Methods for physicians and researchers from various backgrounds. We started with…
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Nov 22 - Nov 27, 2025Division of Clinical Research and TrainingSt. John’s Medical College & Research InstituteBengaluru, IndiaBIRAC - Clinical Trials…
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The Division of Clinical Research and Training, since its inception has been involved in epidemiological studies and clinical trials with the objective of controlling the rising prevalence of cardiovascular disease in India. Initial efforts in this direction included such large registries and case control studies as the CREATE ACS registry and INTERHEART studies. The investigators from the division were involved in the co-development and national coordination of several large intervention trials such as the OASIS series of trials and the POLYCAP series of trials. In recent years, we have moved on to conceiving and executing studies in knowledge translation (the NIH funded SPREAD/ PREPARE trials and the AMEND program respectively).
Stroke is another primary focus areas of research of the Division of Clinical Research and Training. To this end, we are running a large stroke registry (INSPIRE) across 60 centers in India. We have also coordinated a few large important trials in stroke such as the PROFESS and VITATOPS trials.
