Faculty & Staff
Dr. Denis Xavier
Clinical Research and Training
Languages
English, Hindi, Kannada, Tamil
- Overview
- Projects
- Publications
- Other Contributions
- Professor and Head, Department of Pharmacology, St. John's Medical College
- Ex-Vice Dean (PG), St. John's Medical College
- Head, Division of Clinical Research and Training, St. John's Research Institute
- Ph: 080 4946 6140 (Secretary)
Qualification/ Education
- 2005 - 2007; MSc - Clinical Epidemiology and Biostatistics
McMaster University, Hamilton ,Ontario, Canada - 1994 - 1997; MD, Pharmacology
Bangalore University - 1987 - 1992; MBBS
St. John's Medical College, Bangalore
Experience
- Head, Dept. of Pharmacology
St. John's Medical College Hospital
2008 - 2017 and July 2023-till date
Bangalore, India - Head, Division of Clinical Research and Training
St. John's Research Institute
2015 - till date
Bangalore, India - Ex-Vice Dean (PG)
St. John’s Medical College Hospital
2016 - 2019
Bangalore, India - Coordinator
Division of Clinical Research and Training, St. John's Research Institute
1999 - 2015
Bangalore, India - Faculty
St. John's Medical College Hospital
July 1998-till date
Bangalore, India
Fellowship & Membership
- President
SOCHARA (health NGO) 2019 onward, EC member 2013 onwards - Life Member
Cardiological Society of India and Indian Pharmacological Society - Editorial Board member
(a) Nature Reviews Cardiology, UK, (b) Journal of Prevention Cardiology, India; (c) Journal of Clinical Cardiology, New Delhi - Career Guidance
St. John’s Medical College Alumni (2007-2018) - Member
India CLEN, 2010 onwards - Board Member
Community Health Cell - International Editorial Committee Member
Journal of American College of Cardiology, USA, 2014 onwards - Chairman
NIH (NHLBI) Training Subcommittee, Global Health Initiative 2011 - Member
Board of Administration, SJNAHS, 2012- 2014 - Member
Drugs and Therapeutics Committee, SJMCH, 2008 onwards - Member
Chief Editor, Keeping You in Touch, SJNAHS (2016 onwards) - Member
Academic Advisory Board, SJNAHS, 2016 -2020 - International Research Fellow
PHRI, McMaster University, Ontario Canada, 2010 onwards - HOPE-Canada Research Scholar
PHRI, McMaster University, 2005-2007 - Examiner
Graduate Medical Program, Rajiv Gandhi University of Health Sciences since 2004; Post Graduate Medical Program, Rajiv Gandhi University of Health Sciences since 2008; Post Graduate Thesis Reviewer, JIPMER, 2015 onwards; PhD, AIIMS New Delhi, 2017 - Examiner
Masters program, University of Cape Town, 2018 - Supervisor/ Guide
MD Pharmacology Post Graduate Program, Rajiv Gandhi Medical University of Health Sciences since 2006; PhD (Medicine) Program, Rajiv Gandhi University of Health Sciences since October 2012 - Chairperson
Narayana Health Academic Ethics Committee, 2014 - 2019 - Member
NIMHANS Ethics Committee, 2015-2018 & 2022-2025 - Academic Coordinator
Paraclinical Program, St. John’s Medical College, 2013-2016 - Steering Committee Member
World Heart Federation Global Emerging Leaders Program, 2013 onwards; Atrial fibrillation Roadmap Writing Committee, 2015 -2018 - Steering Committee Member / National Coordinator
About 35 large multicenter international clinical research studies - EC Member
Indian Society for Clinical Research (ISCR), 2016 onwards - National Convener
Academic Consortium for Clinical Research in India (ACCRI) of the ISCR, 2018 onwards - Task Force Member
ICMR Cardiovascular Studies Network, 2018 onwards - Member
Scientific Advisory Group on Clinical Trial Network under Biopharma Mission Program, Govt. of India, 2019 onwards - Area Review Panel Member
Biotechnology Industry Research Assistance Council (BIRAC), Department of Biotechnology (DBT), Govt. of India, 2019 onwards - ICMR High Level Expert Committee Member
Jan 2020 onwards - Scientific Reviewer
ICMR, Drugs Controller General of India - Reviewer
Lancet, European Heart Journal, Arch of Int Med - Chairperson
The Heart.org India online radio series – ‘Cardiology in India’ 2014 - Life Member
Cardiological Society of India - Scientific Reviewer
ICMR Projects - Executive Committee member
Indian Society for Clinical Research, Mumbai (April 2017 onward) - National Convener
Academic Consortium for Clinical Research in India (ACCRI) of the ISCR, 2018 onward - ICMR-Member
Digoxin rheumatic heart disease - Member
Project Review Committee – ad hoc proposals and fellowships, ICMR - Member
ICMR - Rheumatic Heart Disease - Member
Indian Stroke Clinical Trial Network (INSTRUCT) - Member
Task Force -Fever or Hypoglycemia & stroke - Member
ICMR-Safe and Rationale Use of Medicine (SRUM) Technical Advisory Group (2023 onwards) - Expert Committee Member
National Health Priority Implementation Research (NHPR)-2016-2025 - Advisory committee member
Centre for Chronic Disease Control (CCDC) - Member
Scientific Advisory Group on Clinical Trial Network under Biopharma Mission Program, BIRAC, DBT, Govt. of India (2019 onwards) - Area Review Panel member
Biotechnology Industry Research Assistance Council (BIRAC), Department of Biotechnology (DBT), Government of India (2019 onwards) - Advisory committee member
Centre for chronic disease control (CCDC)- 2024 onwards
- Head, Dept. of Pharmacology
St. John's Medical College Hospital
2008 - 2017 and July 2023-till date
Bangalore, India - Head, Division of Clinical Research and Training
St. John's Research Institute
2015 - till date
Bangalore, India - Ex-Vice Dean (PG)
St. John’s Medical College Hospital
2016 - 2019
Bangalore, India - Coordinator
Division of Clinical Research and Training, St. John's Research Institute
1999 - 2015
Bangalore, India - Faculty
St. John's Medical College Hospital
July 1998-till date
Bangalore, India
No areas of interest specified.
No groups and associations specified.
The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol
Michael Walsh, David Collister, Martin Gallagher, … Denis Xavier,…Vivekanand Jha, Ron Wald, Amanda Y Wang, Atiya R Faruqui, Fei Yuan, Shun Fu Lee, Alena Kuptsova, Courtney Christou, PJ Devereaux Effects of a hypotension-avoidance versus a hypertension-avoidance strategy on neurocognitive outcomes after noncardiac surgery
Maura Marcucci, Matthew TV Chan, Thomas W Painter, … Denis Xavier, Edith Fleischmann, Chew Yin Wang, Christian S Meyhoff, …PJ Devereaux Improving the clinical trial environment and infrastructure: moving from global resolution to action
Vasee Moorthy, Nandi Siegfried, John Amuasi, Jing Li, Michael Makanga, Karla Soares-Weiser, Sheamini Sivasampu, Denis Xavier, Faiez Zannad, Valerie Snewin Preoperative estimated glomerular filtration rate to predict cardiac events in major noncardiac surgery: a secondary analysis of two large international studies
Pavel S Roshanov, Michael W Walsh, .. Kate Leslie, Matthew TV Chan, Flavia K Borges, Chew Yin Wang, Denis Xavier, Miriam de Nadal, PJ Devereaux Safety and efficacy of tranexamic acid in general surgery
Lily J Park, Maura Marcucci, Denis Xavier, Maria Jose Martinez-Zapata, ..PJ Devereaux A sub-study of the POISE-3 randomised trial examined the effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute kidney injury
Amit X Garg, Maura Marcucci, Meaghan S Cuerden… María José Martínez-Zapata, Chew Yin Wang, Denis Xavier, … Richard Whitlock, PJ Devereaux A sub-study of the POISE-3 randomised trial examined the effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute kidney injury
Amit X Garg, Maura Marcucci, Meaghan S Cuerden… María José Martínez-Zapata, Chew Yin Wang, Denis Xavier, … Richard Whitlock, PJ Devereaux Association of Vascular Risk With Severe vs Non-Severe Stroke: An Analysis of the INTERSTROKE Study
Catriona Reddin, Michelle Canavan, Graeme J Hankey, Shahram Oveisgharan, Peter Langhorne, Xingyu Wang, Annika Rosengren, *Denis Xavier*, Salim Yusuf, Martin J O'Donnell, et al… INTERSTROKE investigators Cost effectiveness analysis of a fixed dose combination pill for primary prevention of cardiovascular disease from an individual participant data meta-analysis.
Andre Lamy, Wesley Tong, Philip Joseph, Peggy Gao, Mark D Huffman, Gholamreza Roshandel, Reza Malekzadeh, Patricio Lopez-Jaramillo, *Prem Pais*, *Denis Xavier*, Alvaro Avezum, Antonio L Dans, Habib Gamra, Salim Yusuf. Carbonated Beverage, Fruit Drink, and Water Consumption and Risk of Acute Stroke: the INTERSTROKE Case-Control Study
Andrew Smyth, Graeme J Hankey, Albertino Damasceno, Helle Klingenberg Iversen, Shahram Oveisgharan, Fawaz Alhussain, Peter Langhorne, Denis Xavier, …Salim Yusuf, Martin O’Donnell Tea and coffee consumption and risk of acute stroke: The INTERSTROKE Study
207. Andrew Smyth, Graeme J Hankey, Peter Langhorne, Catriona Reddin, Danuta Ryglewicz, Annika Rosengren, Denis Xavier, Michelle Canavan, Salim Yusuf, Martin O’Donnell Markers of Periodontal Disease and risk of Stroke: INTERSTROKE case-control study
Robert P Murphy, Graeme J Hankey, Conor Judge, Catriona Reddin, Peter Langhorne, Patricio López–Jaramillo, Charles Mondo, Denis Xavier, Xingyu Wang, Salim Yusuf, Martin O'Donnell Blood pressure variability in acute stroke: Risk factors and association with functional outcomes at 1 month
Catriona Reddin, Robert Murphy, Graeme J Hankey, Xingyu Wang, Peter Langhorne, Shahram Oveisgharan, Denis Xavier, Conor Judge, Andrew Smyth, Salim Yusuf, Martin O'Donnell Pre-morbid sleep disturbance and its association with stroke severity: results from the international INTERSTROKE study
Christine E Mc Carthy, Salim Yusuf, Conor Judge, John Ferguson, Graeme J Hankey, Helle Klingenberg Iversen, Annika Rosengren, Okechukwu Ogah, Luísa Avezum, Denis Xavier, Xingyu Wang, Sumathy Rangarajan, Martin J O'Donnell Timing of Major Postoperative Bleeding Among Patients Undergoing Surgery
202. Alex LE Halme, Pavel S Roshanov, Preetha George, Denis Xavier, HY Lai Carbonated Beverage, Fruit Drink, and Water Consumption and Risk of Acute Stroke: the INTERSTROKE Case-Control Study
209. Andrew Smyth, Graeme J Hankey, Albertino Damasceno, Helle Klingenberg Iversen, Shahram Oveisgharan, Fawaz Alhussain, Peter Langhorne, Denis Xavier, Salim Yusuf, Martin O’Donnell Tea and coffee consumption and risk of acute stroke: The INTERSTROKE Study
Andrew Smyth, Graeme J Hankey, Peter Langhorne, Catriona Reddin, Danuta Ryglewicz, Annika Rosengren, Denis Xavier, Michelle Canavan, Salim Yusuf, Martin O’Donnell Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case-control study
Xingyu Wang, Martin J O'Donnell, Allan Sniderman, Graeme J Hankey, Sumathy Rangarajan, Purnima Rao-Melacini, John Ferguson, Denis Xavier, Salim Yusuf One-year outcomes after discharge from noncardiac surgery and association between pre-discharge complications and death after discharge: analysis of the VISION prospective cohort study
Pavel S Roshanov, Matthew TV Chan, Flavia K Borges, David Conen, CY Wang, Denis Xavier, PJ Devereaux Variations in the prevalence of atrial fibrillation, and in the strength of its association with ischemic stroke, in countries with different income levels: INTERSTROKE case-control study
Robert Murphy, Albertino Damasceno, Catriona Reddin, Graeme J Hankey, Helle K Iversen, Shahram Oveisgharan, Denis Xavier, Patricio Lopez Jamarillo, Xingyu Wang, Salim Yusuf Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery : An International Randomized Controlled Trial
Maura Marcucci 1, Thomas W Painter 2, David Conen 1, Vladimir Lomivorotov 3, Daniel I Sessler 4, Matthew T V Chan 5, Flavia K Borges 1, Kate Leslie 6, Emmanuelle Duceppe 7, María José Martínez-Zapata 8, Chew Yin Wang 9, Denis Xavier 10, Sandra N Ofori 1, Michael Ke Wang 1, Sergey Efremov 11, Giovanni Landoni 12, Ydo V Kleinlugtenbelt 13, Wojciech Szczeklik 14, Denis Schmartz 15, Amit X Garg 16, Timothy G Short 17, Maria Wittmann 18, Christian S Meyhoff 19, Mohammed Amir 20, David Torres 21, Ameen Patel 22, Kurt Ruetzler 4, Joel L Parlow 23, Vikas Tandon 22, Edith Fleischmann 24, Carisi A Polanczyk 25, Andre Lamy 1, Raja Jayaram 26, Sergey V Astrakov 27, William Ka Kei Wu 5, Chao Chia Cheong 9, Sabry Ayad 4, Mikhail Kirov 28, Miriam de Nadal 29, Valery V Likhvantsev 30, Pilar Paniagua 31, Hector J Aguado 32, Kamal Maheshwari 4, Richard P Whitlock 1, Michael H McGillion 1, Jessica Vincent 1, Ingrid Copland 1, Kumar Balasubramanian 1, Bruce M Biccard 33, Sadeesh Srinathan 34, Samandar Ismoilov 3, Shirley Pettit 1, David Stillo 1, Andrea Kurz 4, Emilie P Belley-Côté 1, Jessica Spence 1, William F McIntyre 1, Shrikant I Bangdiwala 1, Gordon Guyatt 35, Salim Yusuf 1, P J Devereaux 1; POISE-3 Trial Investigators and Study Groups Characteristics, clinical practice patterns and outcomes of strokes in India: INSPIRE-A multicentre prospective study
Denis Xavier*, Robert Murphy, *Prem Pais*, Jeyaraj Pandian, Sarma RK Gosala, Nandini Mathur, Dheeraj Khurana, R Sundararajan, Rajeev Gupta, Rajnish Joshi, Somesh Vanchilingam, PN Venkatarathanamma, Soaham Desai, Catriona Reddin, Martin O'Donnell, Salim Yusuf. An Observational Multi-centric COVID-19 Sequelae Study among Health Care Workers
Ajay Kumar Shukla, Shubham Atal, Aditya Banerjee, Ratinder Jhaj, Sadasivam Balakrishnan, Preeta Kaur Chugh, *Denis Xavier*, *Atiya Faruqui*, *Aakanksha Singh*, et al… Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised Trials
Rustam Al-Shahi Salman, Jacqueline Stephen, Jayne F Tierney, Steff C Lewis, David E Newby, Adrian R Parry-Jones, Philip M White, Denis Xavier, Jackie Bosch A randomised controlled trial evaluating a theory-driven, complex intervention centred on task sharing and mobile health to improve self-care and outcomes in heart failure
DY Kamath, J Abdullakutty, BB Granger, S Kulkarni, KB Bhuvana, LJ Salazar, S Shifra, J Idiculla, J Narendra, K Varghese, D Xavier Sleep Patterns and the Risk of Acute Stroke: Results from the INTERSTROKE International Case-Control Study
Christine Eileen Mc Carthy, Salim Yusuf, Conor Judge, Graeme J Hankey, Helle Klingenberg Iversen, Annika Rosengren, Alvaro Avezum, Patricio Lopez-Jaramillo, Denis Xavier Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study
Robert P Murphy, Catriona Reddin, Annika Rosengren, Conor Judge, Graeme J Hankey, … Albertino Damasceno, Denis Xavier, Alvaro Avezum, Xingyu Wang, Peter Langhorne, Salim Yusuf Vitamin D supplementation and adverse skeletal and non-skeletal outcomes in individuals at increased cardiovascular risk: Results from the International Polycap Study (TIPS)-3
P Joseph, P Pais, P Gao, K Teo, D Xavier, P Lopez-Jaramillo, K Yusoff, A Santoso, H Gamra, SH Talukder, C Christou, G Dagenais, J Tyrwhitt, J Bosch, A Dans, S Yusuf Effects of a polypill, aspirin or both on cognitive and functional outcomes. A randomised clinical trial
Bosch JJ, O’Donnel, Gao P, Joseph P, Pais P, Xavier D, Dans A, Lopez J & Yusuf S.et al Secondary prevention with a structured semi-interactive stroke prevention package in INDIA (SPRINT INDIA): a multicentre, randomised controlled trial
Jeyaraj Durai Pandian, Mahesh Pundlik Kate, Padmavathyamma Narayanapillai Sylaja, Dheeraj Khurana, … Prem Pais, Denis Xavier, Parthasarathy Satishchandra, HbA1c Reduction in Dulaglutide-Treated Patients Irrespective of Duration of Diabetes, Microvascular Disease, and BMI: A Post Hoc Analysis From the REWIND Trial
Anita YM Kwan, Hertzel C Gerstein, Jan Basile, *Denis Xavier*, Juan M Maldonado, Sohini Raha, Manige Konig The Anti-Coronavirus Therapy (ACT) trials: design, baseline characteristics, and challenges
Eikelboom J, Rangarajan S, Jolly SS, Belley-Cote EP, *Prem Pais*, *Xavier D*, Whitlock R, Beresh H, Lewis G, Xu L, Chan N, Bangdiwala S, Diaz R, et all.. A novel kidney disease index reflecting both the albumin-to-creatinine ratio and estimated glomerular filtration rate, predicted cardiovascular and kidney outcomes in type 2 diabetes
Hertzel C Gerstein, Chinthanie Ramasundarahettige, Alvero Avezum, Jan Basile, Ignacio Conget, William C Cushman, Gilles R Dagenais, Edward Franek, Mark Lakshmanan, Fernando Lanas, Lawrence A Leiter, *Denis Xavier*, et al.. Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery
Maura Marcucci, Thomas W Painter, David Conen, Kate Leslie, Vladimir V Lomivorotov, Daniel Sessler, Matthew TV Chan, Flavia K Borges, , *Denis Xavier*, Ingrid Copland, Jessica Vincent, Gordon Guyatt, Emily Belley-Cote, Jessica Spence, William McIntyre, Salim Yusuf, PJ Devereaux, Et al Tranexamic acid in patients undergoing noncardiac surgery
PJ Devereaux, Maura Marcucci, *Denis Xavier*, Jessica Vincent, John Eikelboom, Jessica Spence, Toby Richards, Tomas VanHelder, William McIntyre, Gordon Guyatt, Salim Yusuf, Kate Leslie, et al… Usability and feasibility assessment of a smartphone application (Suhriday) for heart failure self-care remote monitoring in an Indian tertiary health care setting: a pilot mixed-methods study
Bhuvana Kolar Bylappa 1, Deepak Y Kamath 2 3, Immaculate Sheela Josephine 3, Jabraan Shaikh 4, Anant Kamath 5, Preethi Rioniz 2, Shruthi Kulkarni 6, Kiron Varghese 4, Denis Xavier 2 3 Alcohol Intake as a Risk Factor for Acute Stroke: The INTERSTROKE Study
Andrew Smyth, Martin O'Donnell, Sumathy Rangarajan, Graeme J Hankey, Shahram Oveisgharan, Michelle Canavan, Clodagh McDermott, Denis Xavier A novel kidney disease index reflecting both the albumin-to-creatinine ratio and estimated glomerular filtration rate predicted cardiovascular and kidney outcomes in type 2 diabetes
Hertzel C Gerstein, Chinthanie Ramasundarahettige, Ignacio Conget, William C Cushman, Edward Franek, Ibrahim Turfanda, Denis Xavier Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial
John W Eikelboom, Sanjit S Jolly, Emilie P Belley-Cote, Alvaro Avezum, Prem Pais, Denis Xavier, Salim Yusuf Role of Proxy Respondents in International Stroke Research: Experience of the INTERSTROKE Study
Maria M Costello, Conor Judge, Catriona Reddin, Sumathy Rangarajan, Peter Langhorne, Denis Xavier, Andrew Smyth, Michelle D Canavan, Salim Yusuf Effects of aspirin in primary prevention of cardiovascular disease in people with chronic kidney disease: results of the TIPS3 trial
Johannes FE Mann, Philip Joseph, Peggy Gao, Prem Pais, Denis Xavier,Jessica Tyrwhitt, Salim Yusuf Association of Lipids, Lipoproteins, and Apolipoproteins with Stroke Subtypes in an International Case Control Study (INTERSTROKE)
Martin J O’Donnell, Matthew McQueen, Allan Sniderman, Guillaume Pare, … Denis Xavier, Prem Pais, Salim Yusuf. Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomised Clinical Trial
Garg AX, Cuerden M, Aguado H,… Denis Xavier et al. Anger or emotional upset and heavy physical exertion as triggers of stroke: the INTERSTROKE study
Andrew Smyth, Martin O’Donnell, Graeme J Hankey, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Denis Xavier, Salim Yusuf Erectile function in men with type 2 diabetes treated with dulaglutide: an exploratory analysis of the REWIND placebo-controlled randomised trial
Harpreet S Bajaj, Hertzel C Gerstein, Purnima Rao-Melacini, Jan Basile, Helen Colhoun, Ignacio Conget, William C Cushman, *Denis Xavier*, Gilles R Dagenais, Edward Franek, Markolf Hanefeld, Matyas Keltai, Mark Lakshmanan, Fernando Lanas, Lawrence A Leiter, Patricio Lopez-Jaramillo, Valdis Pirags, Nana Pogosova , Jeffrey Probstfield, Peter Raubenheimer, Lars Ryden, Jonathan E Shaw, Wayne H-H Sheu The Cost Implications of a Polypill for Primary Prevention in the TIPS-3 Trial
Andre Lamy, Wesley Tong, Philip Joseph, Peggy Gao, *Prem Pais*, Patricio Lopez-Jaramillo, Marjan Walli-Attaei, Tony Dans, *Denis Xavier*, Shamim Talukder, Anwar Santoso, Habib Gamra, Salim Yusuf, TIPS-3 Investigators Topical Controlled Warm Oxygen Therapy Delivered Through a Novel Device (KADAM™) to Treat Diabetic Foot Ulcers: A Randomized Controlled, Open, Pilot Trial
Anirudh V, *Kamath DY*, Ghosh S, *Bhuvana KB*, Sharma S, Maruthy K, *Pais P*, *Xavier D* Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis
Philip Joseph, Gholamreza Roshandel, Peggy Gao, *Prem Pais*, Eva Lonn, *Denis Xavier*, Alvaro Avezum, Jun Zhu, Lisheng Liu, Karen Sliwa, Habib Gamra, Shrikant I Bangdiwala, Koon Teo, Jackie Bosch, Gilles R Dagenais, Reza Malekzadeh, Salim Yusuf, Polypill Trialists’ Collaboration The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019
Gagandeep Singh, Meenakshi Sharma, G Anil Kumar, N Girish Rao, Kameshwar Prasad, Prashant Mathur, Jeyaraj D Pandian, Jaimie D Steinmetz, Atanu Biswas, Pramod K Pal, Sanjay Prakash, PN Sylaja, Emma Nichols, *Denis Xavier*, et al. Three week compared to seven week run-in period length and the assessment of pre-randomization adherence: A study within a trial
David Collister, Lawrence Mbuagbaw, Gordon Guyatt, PJ Devereaux, Karthik K, Tennankore, Gilmar Reis, Laura Sola, *Denis Xavier*, Vivekanand Jha, Martin Gallagher, Antonio L Dans, Wen Liu, Janak de Zoysa, Camilo Félix, Patrick B Mark, Zuo Li, Jessica Tyrwhitt, Joanne Wilkinson, Patrick Sheridan, Fei Yuan, Michael Walsh, ACHIEVE investigators Variations in knowledge, awareness and treatment of hypertension and stroke risk by country income level
Martin O' Donnell, Graeme J Hankey, Sumathy Rangarajan, Siu Lim Chin, Purnima Rao-Melacini, John Ferguson, *Denis Xavier*, Liu Lisheng, Hongye Zhang, *Prem Pais*, Patricio Lopez-Jaramillo, Albertino Damasceno, Peter Langhorne, Annika Rosengren, Antonio L Dans, Ahmed Elsayed, Alvaro Avezum, Charles Mondo, Andrew Smyth, Conor Judge, Hans-Christoph Diener, Danuta Ryglewicz, Anna Czlonkowska, Nana Pogosova, Christian Weimar, Romana Iqbal, Rafael Diaz, Khalid Yusoff, Afzalhussein Yusufali, Aytekin Oguz, Xingyu Wang, Ernesto Penaherrera, Fernando Lanas, Okechukwu Samuel Ogah, Adensola Ogunniyi, Helle K Iversen, German Malaga, Zvonko Rumboldt, Shahram Oveisgharan, Fawaz AlHussain, Magazi Daliwonga, Yongchai Nilanont, Salim Yusuf Hydroxychloroquine for SARS CoV2 Prophylaxis in Healthcare Workers – A Multi-centric Cohort Study Assessing Effectiveness and Safety
Badyal Dinesh, Chandy Sujith J, Chugh Preeta Kaur, Faruqui Atiya, Gupta Yk, Hazra Avijit, Kamat Sandhya, Kamboj Vp, Kaul Rajani, Kshirsagar Nilima, Maulik Subir, Medhi Bikash, Menon Geetha, Ranjalkar Jaya, Rao Vishnu, Shetty Yashashri, Tripathi Raakhi, *Xavier Denis* A qualitative, grounded theory exploration of the determinants of self-care behavior among Indian patients with a lived experience of chronic heart failure
*Deepak Y Kamath*, *KB Bhuvana*, Luke Joshua Salazar, Kiron Varghese, Anant Kamath, Jyoti Idiculla, *Prem Pais*, Shruthi Kulkarni, Bradi B Granger, *Denis Xavier* A qualitative, grounded theory exploration of the determinants of self-care behaviour among Indian patients with chronic heart failure
Deepak Y Kamath 1 2, K B Bhuvana 1, Luke Joshua Salazar 3, Kiron Varghese 4, Anant Kamath 5, Jyoti Idiculla 6, Prem Pais 2, Shruthi Kulkarni 6, Bradi B Granger 7, Denis Xavier 1 2 Safety of hydroxychloroquine in healthcare workers for COVID-19 prophylaxis.
• Faruqui AR, Xavier D, Kamat SK, Chandy SJ, Medhi B, Tripathi RK, Shetty YC, Raj JM, Kaushal S, Balakrishnan S, Atal S, Tripathi SK, Badyal DK, Dikshit H, Roy SS, Trivedi N, Chatterjee S, Desai C, Tripathi CD, Rege NN, Gupta P, Raveendran R, Kaul R, Kshirsagar NA. The Cost Implications of Dabigatran in Patients with Myocardial Injury After Non-Cardiac Surgery
Andre Lamy, Wesley Tong, Rajibul Mian, Jessica Vincent, Denis Xavier, PJ Devereaux et al Prevalence of modifiable cardiovascular risk factors among coffee estate workers in rural South India (CARE)
Sitarah Mathias, Akhil Xavier Joseph, Tanvi Jadhav, Denis Xavier Efficacy and Safety of Dulaglutide in Older Patients: A post hoc Analysis of the REWIND trial
Matthew C Riddle, Hertzel C Gerstein, Denis Xavier, William C Cushman, Lawrence A Leiter, et al Urgently seeking efficiency and sustainability of clinical trials in global health
Jay JH Park, Rebecca F Grais, Monica Taljaard, Jean B Nachega, Nathan Ford, Denis Xavier, et al Randomised trials at the individual level
Jay JH Park, Nathan Ford, Denis Xavier, Per Ashorn, Rebecca F Grais, Zulfiqar A Bhutta, et al The role and challenges of cluster randomised trials for global health
Louis Dron, Monica Taljaard, Yin Bun Cheung, Rebecca Grais, Nathan Ford, Denis Xavier, et al Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study
Jackie Bosch, Eva M Lonn, Lisheng Liu, Patricio Lopez-Jaramillo, Prem Pais, Denis Xavier, et al Premature permanent discontinuation of apixaban or warfarin in patients with atrial fibrillation
Anthony P Carnicelli, Sana M Al-Khatib, Denis Xavier, Frederik Dalgaard, Peter D Merrill, Daniel M Wojdyla, Basil S Lewis, Michael Hanna, John H Alexander, Renato D Lopes, Lars Wallentin, Christopher B Granger Health and economic impact of air pollution in the states of India: the Global Burden of Disease Study 2019
Anamika Pandey, Michael Brauer, Maureen L Cropper, Kalpana Balakrishnan, Prashant Mathur, Sagnik Dey, Burak Turkgulu, G Anil Kumar, Denis Xavier, Polypill with or without Aspirin in Persons without Cardiovascular Disease
Salim Yusuf, D.Phil. Philip Joseph, M.D., Antonio Dans, M.D., Peggy Gao, M.Sc., Koon Teo, Ph.D., Denis Xavier, M.D., Patricio López-Jaramillo, Situational analysis of practice patterns and challenges in cardiovascular disease management: A qualitative study
Farah Naaz Fathima, Twinkle Agrawal, Padmini Nidhin, *Denis Xavier* Urinary Sodium and Potassium, and Risk of Ischaemic and Haemorrhagic Stroke (INTERSTROKE): a case-control study
Judge C, O'Donnell MJ, Hankey GJ, Rangarajan S, Chin SL, Rao-Melacini P, Ferguson J, Smyth A, Xavier D, Lisheng L, Zhang H, Lopez-Jaramillo P, Damasceno A, Langhorne P, Rosengren A, Dans AL, Elsayed A, Avezum A, Mondo C, Ryglewicz D, Czlonkowska A, Pogosova N, Weimar C, Diaz R, Yusoff K, Yusufali A, Oguz A, Wang X, Lanas F, Ogah OS, Ogunniyi A, Iversen HK, Malaga G, Rumboldt Z, Oveisgharan S, Hussain FA, Yusuf S Patient and caregiver reported facilitators of self-care among patients with chronic heart failure: report from a formative qualitative study
Kamath DY, Bhuvana KB, Dhiraj RS, Xavier D, Varghese K, Salazar LJ, Granger CB, Pais P, Granger BB One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery
Sessler DI, Conen D, Leslie K, Yusuf S, Popova E, Graham M, Kurz A, Villar JC, Mrkobrada M, Sigamani A, Biccard BM, Meyhoff CS, Parlow JL, Guyatt G, Xavier D, Chan MTV, Kumar PA, Forget P, Malaga G, Fleischmann E, Amir M, Torres D, Wang CY, Paniagua P, Berwanger O, Srinathan S, Landoni G, Manach YL, Whitlock R, Lamy A, Balasubramanian K, Gilron I, Turan A, Pettit S, Devereaux PJ; Perioperative Ischemic Evaluation-2 Trial (POISE-2) Investigators. Regional variation in clinical characteristics and outcomes in patients with atrial fibrillation: Findings from the ARISTOTLE trial
Bahit MC, Granger CB, Alexander JH, Mulder H, Wojdyla DM, Hanna M, Goto S, Xavier D, Verheugt FWA, Lanas F, Hijazi Z, Wallentin L, Lopes RD Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial
149. Cukierman-Yaffe, Tali; Gerstein, Hertzel C; Colhoun, Helen M; Diaz, Rafael; García-Pérez, Luis-Emilio; Lakshmanan, Mark; Bethel, Angelyn; Xavier, Denis Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial
Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, *Pais P*, *Xavier D*, Atisso CM, et al.. The impact of air pollution on deaths, disease burden, and life expectancy across the states of India: the Global Burden of Disease Study 2017.
K Balakrishnan, S Dey, T Gupta, RS Dhaliwal, M Brauer, AJ Cohen, *D Xavier*, et al.. Prescription Pattern, Short-Term Outcomes, and Its Determinants in Patients With Chronic Kidney Disease Attending a Tertiary Care Hospital
Mamadi RK, Sathish R, Selvaraj DR, Rathore R, Jose JV, Xavier D Cardiovascular risk factor reduction by community health workers in rural India: A cluster randomized trial
Joshi R, Agrawal T, Fathima F, Usha T, Thomas T, Misquith D, Kalantri S, Chidambaram N, Raj T, Singamani A, Hegde S, Xavier D, Devereaux PJ, Pais P, Gupta R, Yusuf S Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial
Washam JB, Hohnloser SH, Lopes RD, Wojdyla DM, Vinereanu D, Alexander JH, Gersh BJ, Hanna M, Horowitz J, Hylek EM, Xavier D, Verheugt FWA, Wallentin L, Granger CB; ARISTOTLE Committees and Investigators. Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome treated medically or with percutaneous coronary intervention or undergoing elective percutaneous coronary intervention: insights from the AUGUSTUS trial
Stephan Windecker, Renato D Lopes, Tyler Massaro, Charlotte Jones-Burton, Christopher B Granger, Robert C Welsh, Denis Xavier, Roxana Mehran, John H Alexander et al Alirocumab reduces total hospitalizations and increases days alive and out of hospital in the ODYSSEY OUTCOMES trial
142. Michael Szarek, Ph Gabriel Steg, Dina DiCenso, Deepak L Bhatt, Vera A Bittner, Andrzej Budaj, Rafael Diaz, Shaun G Goodman, Nina Gotcheva, J Wouter Jukema, Robert Pordy, Matthew T Roe, Timothée Sourdille, Harvey D White, Denis Xavier, et al. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial.
Ray, Kausik K; Colhoun, Helen M; Szarek, Michael; Baccara-Dinet, Marie; Bhatt, Deepak L; Bittner, Vera A; Budaj, Andrzej J; Diaz, Rafael; Goodman, Shaun G; Hanotin, Corinne; Denis Xavier et al Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial
M Szarek, HD White, GG Schwartz, M Alings, DL Bhatt, VA Bittner, D Xavier et al Hypertension: The most important non communicable disease risk factor in India
Gupta R, Xavier D Divergent trends in ischaemic heart disease and stroke mortality in India from 2000 to 2015: a nationally representative mortality study
Ke C, Gupta R, Xavier D, Prabhakaran D, Mathur P, Kalkonde YV, Kolpak P, Suraweera W, Jha P; Million Death Study Collaborators. Design of a Randomized Placebo-Controlled Trial to Assess Dabigatran and Omeprazole in Patients with Myocardial Injury after Noncardiac Surgery (MANAGE)
Duceppe E, Yusuf S, Tandon V, Rodseth R, Biccard BM, Xavier D, Szczeklik W, Meyhoff CS, Franzosi MG, Vincent J, Srinathan SK, Parlow J, Magloire P, Neary J, Rao M, Chaudhry NK, Mayosi B, de Nadal M, Popova E, Villar JC, Botto F, Berwanger O, Guyatt G, Eikelboom JW, Sessler DI, Kearon C, Pettit S, Connolly SJ, Sharma M, Bangdiwala SI, Devereaux PJ Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery
Graham MM, Sessler DI, Parlow JL, Biccard BM, Guyatt G, Leslie K, Chan MTV, Meyhoff CS, Xavier D, Sigamani A, Kumar PA, Mrkobrada M, Cook DJ, Tandon V, Alvarez-Garcia J, Villar JC, Painter TW, Landoni G, Fleischmann E, Lamy A, Whitlock R, Le Manach Y, Aphang-Lam M, Cata JP, Gao P, Terblanche NCS, Ramana PV, Jamieson KA, Bessissow A, Mendoza GR, Ramirez S, Diemunsch PA, Yusuf S, Devereaux PJ Impact of a multifaceted educational intervention on oral anticoagulation (OAC) use in atrial fibrillation (AF) patients according to aspirin use at baseline: insights from impact-AF trial.
Jie Jiang, Ying Xian, Hussein Al-Khalidi, Maria Bahit, Renato Lopes, Dragos Vinereanu, *Denis Xavier*, He Pengkang, He Wensheng, Andrea Ciobanu, *Deepak Kamanth*, et al.. Low quality cardiovascular care is important coronary risk factor in India
Gupta R, Khedar RS, Gaur K, Xavier D First Stroke Reduced 44 Percent by Well Tolerated Medications. Stroke Outcomes From the Heart Outcomes Prevention Evaluation 3 Study
Bosch J, Lonn E, Zhu J, Pais P, Xavier D, Dans A, Diaz R, Hart R, Yusuf S Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016
Fullman N, Yearwood J, Abay SM, Abbafati C, Abd-Allah F, Abdela J, Xavier D, et al; GBD 2016 Healthcare Access and Quality Collaborators Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial
Devereaux PJ, Duceppe E, Guyatt G, Tandon V, Rodseth R, Biccard BM, Xavier D, Szczeklik W, Meyhoff CS, et al; MANAGE Investigators Practice patterns and outcomes after stroke across countries at different economic levels (INTERSTROKE): an international observational study
Langhorne P, O'Donnell M, Chin S, Zhang H, Xavier D, Avezum A, et al Effect of intensive lifestyle modification & metformin on cardiovascular risk in prediabetes: A pilot randomised control trial
S Kulkarni, D Xavier, B George, S Umesh, S Fathima, G Bantwal Design and baseline characteristics of participants in the Researching Cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide
Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, Probstfield J, Riddle MC, Rydén L, Xavier D et al The International Polycap Study-3 (TIPS-3): Design, baseline characteristics and challenges in conduct
P Joseph, P Pais, AL Dans, J Bosch, D Xavier, P Lopez-Jaramillo, et al The increasing burden of diabetes and variations among the states of India: the Global Burden of Disease Study 1990–2016
N Tandon, RM Anjana, V Mohan, T Kaur, A Afshin, K Ong, D Xavier et al. The changing patterns of cardiovascular diseases and their risk factors in the states of India: the Global Burden of Disease Study 1990–2016
D Prabhakaran, P Jeemon, M Sharma, GA Roth, C Johnson, D Xavier et al Practice patterns and outcomes after stroke across countries at different economic levels (INTERSTROKE): an international observational study
P Langhorne, MJ O'Donnell, SL Chin, H Zhang, D Xavier, A Avezum, et al. Improving Evidence for Implementation of Guideline-Based Care in Low- and Middle-Income Countries
Granger CB, Xavier D Design and baseline characteristics of participants in the Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide
Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Xavier D, et al. Nations within a nation: variations in epidemiological transition across the states of India, 1990-2016 in the Global Burden of Disease Study
India State-Level Disease Burden Initiative Collaborators Regional differences in presentation and antithrombotic treatment of patients with atrial fibrillation: Baseline characteristics from a clustered randomized trial to IMProve treatment with AntiCoagulanTs in patients with atrial fibrillation (IMPACT-AF)
Vinereanu D, Al-Khalidi HR, Rao MP, He W, Lopes RD, Bahit CM, Ciobanu AO, Fox KA, Pokorney SD, Xian Y, Jiang J, Kamath DY, Berwanger O, Tajer C, Huo Y, Xavier D, Granger CB A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial
Dragos Vinereanu , Renato D Lopes , M Cecilia Bahit , Denis Xavier , Jie Jiang , Hussein R Al-Khalidi , Wensheng He , Ying Xian , Andrea O Ciobanu , Deepak Y Kamath , Kathleen A Fox , Meena P Rao , Sean D Pokorney , Otavio Berwanger , Carlos Tajer , Pedro G M de Barros E Silva , Mayme L Roettig , Yong Huo , Christopher B Granger IMPACT-AF investigators The World Heart Federation Roadmap for Nonvalvular Atrial Fibrillation
Murphy A, Banerjee A, Breithardt G, Camm AJ, Commerford P, Xavier D, et al. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015
Wolfe CDA, Won S, Workicho A, Workie SB, Wubshet M, Xavier D, et al. Predictors, Prognosis, and Management of New Clinically Important Atrial Fibrillation After Noncardiac Surgery: A Prospective Cohort Study
Alonso-Coello P, Cook D, Xu SC, Sigamani A, Berwanger O, Xavier D, et al. Primary Healthcare-based Diabetes Registry in Puducherry: Design and Methods
Lakshminarayanan S, Kar SS, Gupta R, Xavier D, Bhaskar Reddy SV Association of postoperative high-sensitivity troponin levels with myocardial injury and 30-day mortality among patients undergoing noncardiac surgery
Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, et al. Use of interacting drugs did not modify treatment effects of apixaban versus warfarin for atrial fibrillation: results from the Aristotle trial
111. Jeffrey B. Washam, Stefan Hohnloser, Daniel Wojdyla, Dragos Vinereanu, John Alexander, Denis Xavier, et al Uses of polypills for cardiovascular disease and evidence to date
Huffman MD, Xavier D, Perel P Global, regional, and national Incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015
Vos T, Allen C, Arora M, Cornaby L, Dandona L, *Xavier D*, et al.. Non-physician health workers for improving adherence to medications and healthy lifestyle following acute coronary syndrome: 24-month follow-up study
KK Sharma, R Gupta, M Mathur, V Natani, S Lodha, D Xavier et al. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
GBD 2015 DALYs and HALE Collaborators Importance of Conventional and Emerging Risk Factors for Stroke in Different Regions of the World and in Different Ethnic Groups: A Pilot Case-control Study (INTERSTROKE)
Dr. Prem Pais, Dr. Denis Xavier No Others Contributions details available.